Effects of chronic administration of fruit extract (Citrus unshiu MARC) on endothelial dysfunction in streptozotocin-induced diabetic rats
Effects of chronic administration of fruit extract (Citrus unshiu MARC) on endothelial dysfunction in streptozotocin-induced diabetic rats
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DOI：
10.1248/bpb.28.267
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发表时间：
2005-02-01
影响因子：
2
通讯作者：
Sugiura, M
中科院分区：
文献类型：
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作者：
Kamata, K;Kobayashi, T;Sugiura, M
我们研究了长期服用水果提取物(温州蜜橘)对链脲佐菌素(STZ)诱导的糖尿病大鼠主动脉内皮细胞功能障碍的影响。给药10周后，糖尿病大鼠主动脉中乙酰胆碱(ACh)诱导的内皮依赖性松弛得到保护，但硝普钠(SNP)诱导的内皮非依赖性松弛不受其影响。在年龄匹配的对照组大鼠中，长期给予水果提取物对ACh或SNP诱导的主动脉松弛没有影响。在STZ诱导的糖尿病大鼠中，总胆固醇、低密度脂蛋白(LDL)胆固醇和甘油三酯水平的升高并未通过水果提取物治疗而恢复正常。这些结果表明，温州蜜柑提取物在不降低血浆胆固醇的情况下，可以保护STZ诱导的糖尿病大鼠的主动脉内皮细胞功能。这种有益的效果可能是由于这种提取物保护一氧化氮免受氧自由基灭活的影响。
We investigated the effects of chronic administration of fruit extract (Citrus unshiu MARC) on the endothelial dysfunction seen in aortae from streptozotocin (STZ)-induced diabetic rats. A ten-week administration of this fruit extract preserved acetylcholine (ACh)-induced endothelium-dependent relaxation, but not sodium nitroprusside (SNP)-induced endothelium-independent relaxation, in the diabetic aorta. In age-matched control rats, chronic administration of the fruit extract had no influence on the ACh- or SNP-induced aortic relaxation. The increased total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride levels seen in STZ-induced diabetic rats were not normalized by fruit-extract treatment. These results suggest that Citrus unshiu MARC extract preserves endothelial function in the aorta in STZ-induced diabetic rats without lowering plasma cholesterol. This beneficial effect may be due to this extract protecting of nitric oxide against inactivation by oxygen free radicals.