Genetics of Cellular, Individual, Family, and Population Variability
Genetics of Cellular, Individual, Family, and Population Variability
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细胞、个体、家族和群体变异的遗传学
DOI：
10.1093/oxfordjournals.jhered.a111449
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发表时间：
1994
影响因子：
3.1
通讯作者：
P. Hedrick
中科院分区：
文献类型：
--
作者：
P. Hedrick
这本书收录了杰克·舒尔的同事和以前的学生的18篇文章，是在蒙大拿州举行的庆祝他退休的研讨会的产物。该卷的主题是人类的遗传变异，其贡献分为其标题的四个主要部分：细胞，个体，家庭和群体变异。这些文章通常是对贡献者感兴趣的特定领域的评论或介绍。对于读者来说，所提供的一些参考文献将对特定主题提供更全面的介绍。第一部分，细胞变异，包含了维斯关于癌症遗传基础的章节和查克拉瓦蒂关于复杂疾病遗传基础的章节。两者都总结了理解各自主题的理论方法。第二部分，个体变异，由Neel和Otake写了两章，总结了Schull和他的同事对日本近亲繁殖和日本原子弹辐射影响的广泛研究。当尼尔和舒尔在25年前记录近亲繁殖对各种性状的影响通常很小时，他们能够令人满意地解释这一现象。然而，在这里的一个发人深省的总结中，尼尔反思道：“我认为我们还没有能够果断地处理这些问题中的大多数。似乎正在出现的是一个相互关联的近亲繁殖效应的潜在解释家族。”本节的另外两个贡献是Ferrell对几种疾病的体细胞遗传变异的研究，以及Boerwinkle和Hallman对影响脂质代谢的变异的基因型-环境相互作用的研究。
This volume of 18 contributions of colleagues and former students of Jack Schull is the product of a symposium held in Montana in celebration of his retirement. The theme of the volume is genetic variation in humans, with contributions divided into the four major sections of its title: cellular, individual, family, and population variability. The articles are generally reviews or introductions to specific areas of interest to the contributors. For readers, some of the references given will provide a more thorough introduction to particular topics.The first section, cellular variability, contains chapters by Weiss on the genetic basis of cancer and by Chakravarti on the genetic basis of complex diseases. Both summarize theoretical approaches to understanding the respective topics. The second section, individual variability, contains two chapters by Neel and Otake that summarize the research on the extensive studies by Schull and his colleagues on the effects of inbreeding in Japan and of radiation from the atomic bombs dropped on Japan. When Neel and Schull documented the generally small influence of inbreeding on various traits over 25 years ago, they were able to explain this phenomenon to their satisfaction. However, in a sobering summary here, Neel reflects," I do not feel we are yet in a position to deal decisively with most of these questions. What does seem to be emerging is a family of interrelated potential explanations of inbreeding effects." The other two contributions in this section are by Ferrell on somatic genetic variation in several diseases and by Boerwinkle and Hallman on genotype-environment interaction for variants that affect lipid metabolism.