Fine-scale topography in sensory systems: insights from Drosophila and vertebrates.
Fine-scale topography in sensory systems: insights from Drosophila and vertebrates.
复制标题
DOI：
10.1007/s00359-015-1022-7
复制
发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Ye B
中科院分区：
文献类型：
--
作者：
Kaneko T;Ye B
为了对感觉刺激的位置进行编码，感觉回路通过突触前和突触后神经元之间的特定点对点连接在中枢神经系统中形成地形图。在脊椎动物视觉系统中，地形图的建立涉及粗略地形的形成，然后是区分相邻神经元轴突末端的精细地形的形成。众所周知，引导分子的宽梯度形式的内在差异指示粗尺度地形，而精细尺度地形需要神经元活动。另一方面，对果蝇视觉系统的研究表明，相邻神经元轴突末端之间细胞粘附的内在差异指示着精细尺度的地形。最近对果蝇体感系统中活动依赖性地形的研究揭示了神经元活动在感觉神经元之间产生分子差异以建立精细地形的作用，这暗示了一个保守的原理。在这里，我们回顾了果蝇和脊椎动物的研究结果，并提出了一个精细尺度地形的综合模型。
To encode the positions of sensory stimuli, sensory circuits form topographic maps in the central nervous system through specific point-to-point connections between pre- and post-synaptic neurons. In vertebrate visual systems, the establishment of topographic maps involves the formation of a coarse topography followed by that of fine-scale topography that distinguishes the axon terminals of neighboring neurons. It is known that intrinsic differences in the form of broad gradients of guidance molecules instruct coarse topography while neuronal activity is required for fine-scale topography. On the other hand, studies in the Drosophila visual system have shown that intrinsic differences in cell adhesion among the axon terminals of neighboring neurons instruct the fine-scale topography. Recent studies on activity-dependent topography in the Drosophila somatosensory system have revealed a role of neuronal activity in creating molecular differences among sensory neurons for establishing fine-scale topography, implicating a conserved principle. Here we review the findings in both Drosophila and vertebrates and propose an integrated model for fine-scale topography.