GASTRIC-ACID AND VAGUS NERVE RESPONSE TO GABA AGONIST BACLOFEN
GASTRIC-ACID AND VAGUS NERVE RESPONSE TO GABA AGONIST BACLOFEN
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DOI：
10.1016/0024-3205(85)90143-2
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发表时间：
1985-01-01
期刊：
影响因子：
6.1
通讯作者：
NOVIN, D
中科院分区：
文献类型：
--
作者：
GOTO, Y;TACHE, Y;NOVIN, D
巴氯芬[β- [（对氯苯基）-GABA]是GABA的亲脂性衍生物，本文研究了它对麻醉大鼠左颈迷走神经传出活动的影响。巴氯芬（4 mg/kg，s.c.）在多纤维迷走神经制备中产生神经放电。迷走神经激活的时间过程与每2分钟记录一次的胃酸分泌刺激曲线相关。阿托品预处理（1 mg/kg）并没有改变巴氯芬刺激迷走神经活动。GABAB受体激动剂通过不依赖于与毒蕈碱受体相互作用的机制刺激副交感神经流出，导致刺激胃酸分泌。
Baclofen [.beta.-(p-chlorophenyl)-GABA], a lipophilic derivative of GABA, was studied for its effect upon the efferent activity of the left cervical vagus in urethane-anesthetized rats. Baclofen (4 mg/kg, s.c.) produce neural discharges in the multifiber vagus preparation. The time course of vagal activation is well correlated with the profile of stimulation of gastric acid secretion recorded every 2 min. Atropine pretreatment (1 mg/kg) did not modify baclofen stimulation of vagal activity. A GABAB receptor agonist stimulates the parasympathetic outflow through mechanisms independent of interaction with muscarinic receptors leading to stimulation of gastric acid secretion.