Prediction of BRAF mutation status in glioblastoma multiforme by preoperative ring enhancement appearances on MRI.
Prediction of BRAF mutation status in glioblastoma multiforme by preoperative ring enhancement appearances on MRI.
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术前MRI环形增强表现预测多形性胶质母细胞瘤BRAF突变状态
DOI：
10.3389/fonc.2022.937345
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发表时间：
2022
影响因子：
4.7
通讯作者：
Chen, Ming
中科院分区：
文献类型：
--
作者：
Cai, Xiaomin;Chen, Zheng;Chang, Bowen;Tu, Ming;Li, Shiting;Wang, Xuhui;Chen, Ming
背景磁共振成像（MRI）上的环形增强是GBM的一个重要特征。尽管患有V600 E中BRAF突变（MUT BRAF）的多形性胶质母细胞瘤（GBM）的患者受益于BRAF靶向抑制剂，但环增强和MUT BRAF之间的关系仍然难以捉摸。本研究旨在探讨BRAF基因突变状态与环状增强的关系，以指导MUT BRAF GBM的术前靶向治疗。方法比较MUT BRAF与WT BRAF GBM的患者人群、临床资料及MRI特征性环状强化表现。采用受试者工作特征（ROC）曲线分析评价其鉴别诊断意义。用列线图预测BRAF基因突变状态。此外，在有或没有MUT BRAF的上皮样GBM（E-GBM）之间重新分析所有变量。结果与WT BRAF GBM相比，MUT BRAF GBM具有特定的环状强化表现，表现为多个环状、多个定位叶、环状形态规则、环状厚度均匀、环状直径较小。所有变量组合的曲线下面积（AUC）为0.929。列线图已制定和验证。在有或没有MUT BRAF的E-GBM之间的再分析结果与上述结果相似。环数、定位叶数和环形组合的AUC为0.962。结论GBM特征性的环状强化表现对术前预测BRAF突变状态有重要意义，尤其是E-GBM。进一步的大规模病例研究可能为指导GBM合并MUT BRAF患者的靶向药物预处理提供更多的证据。
Background Ring enhancement on magnetic resonance imaging (MRI) is an important characteristic of GBM. Though patients suffering from glioblastoma multiforme (GBM) with BRAF mutation (MUT BRAF) in V600E benefit from BRAF-targeted inhibitors, the relationship between ring enhancement and MUT BRAF remains elusive. The purpose of this study was to investigate the relationship between BRAF mutation status and the appearance of ring enhancement so as to guide preoperative targeted therapy for MUT BRAF GBM. Methods Patient’s population, clinical data and characteristic ring enhancement appearances on MRI were compared between GBM with MUT BRAF and GBM with WT BRAF. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the differential diagnostic significance. A nomogram was developed to predict the mutation status of BRAF. Moreover, all the variables were re-analyzed between epithelioid GBM (E-GBM) with or without MUT BRAF. Results Compared to GBM with WT BRAF, GBM with MUT BRAF had specific ring enhancement appearances with multiple rings, multiple located lobes, regular shape of ring, uniform thickness of ring and smaller diameter of ring. Area under the curve (AUC) of all the variables’ combination was 0.929. The nomogram was developed and validated. The re-analyzed results between E-GBM with or without MUT BRAF were similar to these above. AUC of the combination of quantity of ring, quantity of located lobe and shape of ring was 0.962. Conclusion The characteristic ring enhancement appearances of GBM may play an important role in predicting BRAF mutation status preoperatively, especially in E-GBM. Further study with larger cases may provide more evidences to guide the pretreatment of targeted medicine for GBM patients with MUT BRAF in future.
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影响因子：
3.9
作者：
Lim-Fat MJ;Song KW;Iorgulescu JB;Andersen BM;Forst DA;Jordan JT;Gerstner ER;Reardon DA;Wen PY;Arrillaga-Romany I
通讯作者：
Arrillaga-Romany I
dabrafenib患有复发性，BRAF V600E突变的恶性神经胶质瘤和瘦脑脑疾病的患者。
影响因子：
4.2
作者：
Burger MC;Ronellenfitsch MW;Lorenz NI;Wagner M;Voss M;Capper D;Tzaridis T;Herrlinger U;Steinbach JP;Stoffels G;Langen KJ;Brandts C;Senft C;Harter PN;Bähr O
通讯作者：
Bähr O
影响因子：
13.3
作者：
Iser, Isabele C.;Pereira, Mariana B.;Wink, Marcia R.
通讯作者：
Wink, Marcia R.
影响因子：
45.3
作者：
Lee, Eudocia Q.;Ruland, Sandra;Santagata, Sandro
通讯作者：
Santagata, Sandro
DOI：
10.1126/science.1164382
发表时间：
2008-09-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Parsons DW;Jones S;Zhang X;Lin JC;Leary RJ;Angenendt P;Mankoo P;Carter H;Siu IM;Gallia GL;Olivi A;McLendon R;Rasheed BA;Keir S;Nikolskaya T;Nikolsky Y;Busam DA;Tekleab H;Diaz LA Jr;Hartigan J;Smith DR;Strausberg RL;Marie SK;Shinjo SM;Yan H;Riggins GJ;Bigner DD;Karchin R;Papadopoulos N;Parmigiani G;Vogelstein B;Velculescu VE;Kinzler KW
通讯作者：
Kinzler KW