Effects of S-adenosylhomocysteine and analogs on Epstein-Barr virus-induced transformation, expression of the Epstein-Barr virus capsid antigen, and methylation of Epstein-Barr virus DNA.
Effects of S-adenosylhomocysteine and analogs on Epstein-Barr virus-induced transformation, expression of the Epstein-Barr virus capsid antigen, and methylation of Epstein-Barr virus DNA.
复制标题
S-腺苷高半胱氨酸和类似物对 Epstein-Barr 病毒诱导的转化、Epstein-Barr 病毒衣壳抗原的表达以及 Epstein-Barr 病毒 DNA 甲基化的影响。
DOI：
10.1128/jvi.61.1.221-224.1987
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发表时间：
1987
影响因子：
5.4
通讯作者：
Henderson,EE
中科院分区：
文献类型：
--
作者：
Long,WK;Fronko,GE;Lindemeyer,RG;Wu,B;Henderson,EE
S-Adenosylhomocysteine was found to have no effect on Epstein-Barr virus-induced transformation of B-lymphocytes and to stimulate viral capsid antigen expression only slightly in the FF41-1 cell line. In contrast, the S-adenosylhomocysteine analogs sinefungin and S-isobutyladenosine inhibited Epstein-Barr virus transformation and induced a significant increase in the numbers of cells expressing the viral capsid antigen. An inverse relationship between levels of viral DNA methylation and gene expression was demonstrated.
