Influence of background vagal C-fiber activity on eupneic breathing pattern in anesthetized dogs.
Influence of background vagal C-fiber activity on eupneic breathing pattern in anesthetized dogs.
复制标题
背景迷走神经 C 纤维活动对麻醉犬平静呼吸模式的影响。
DOI：
10.1152/jappl.1995.79.2.600
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Green,JF
中科院分区：
文献类型：
--
作者：
Schelegle,ES;Mansoor,JK;Green,JF
在19只狗麻醉甲苯噻嗪和α-氯醛糖，我们研究了背景迷走神经C-纤维活动对呼吸模式的影响，使用改良的神经周围辣椒素治疗。在七只狗中，我们通过记录辣椒素应用前后的复合动作电位来测试这种治疗的功效。在其余的12只狗，我们研究了迷走神经周围辣椒素对Hering-Breuer呼气易化性膨胀反射，肺化学反射和呼吸模式（潮气量和呼气和吸气时间）的影响。复合动作电位A波的峰高和积分均未受到显著影响。但复合动作电位C波的峰高和积分受到明显影响。但复合动作电位C波的峰高和积分明显降低。神经周辣椒素后，有髓纤维引发的Hering-Breuer反射保持完整，但C纤维引发的肺化学反射被取消。神经周辣椒素增加潮气量（0.399 +/- 0.031至0.498 +/- 0.058升; P < 0.05），呼气时间（3.62 +/- 0.31至4.82 +/- 0.68 s; P < 0.05），吸气时间（1.49 +/- 0.12至1.72 +/- 0.17 s; P < 0.10）和每次呼吸的总时间（5.11 +/- 1.08至6.54 +/- 0.82 s; P < 0.05）。我们得出结论，背景迷走神经C纤维活动对潮气量产生抑制作用，对呼吸频率产生兴奋作用。
In 19 dogs anesthetized with xylazine and alpha-chloralose, we examined the influence of background vagal C-fiber activity on the breathing pattern using a modified perineural capsaicin treatment. In seven dogs, we tested the efficacy of this treatment by recording compound action potentials before and after capsaicin application. In the remaining 12 dogs, we examined the effect of vagal perineural capsaicin on the Hering-Breuer expiratory facilitatory inflation reflex, pulmonary chemoreflex, and breathing pattern (tidal volume and expiratory and inspiratory times). Neither the peak height nor integral of the A wave of the compound action potential was significantly affected. However, the peak height and integral of the C wave of the compound action potential were significantly affected. However, the peak height and integral of the C wave of the compound action potential were significantly reduced. The myelinated fiber-initiated Hering-Breuer reflex remained intact after perineural capsaicin, but the C-fiber-initiated pulmonary chemoreflex was abolished. Perineural capsaicin increased tidal volume (0.399 +/- 0.031 to 0.498 +/- 0.058 liter; P < 0.05), expiratory time (3.62 +/- 0.31 to 4.82 +/- 0.68 s; P < 0.05), inspiratory time (1.49 +/- 0.12 to 1.72 +/- 0.17 s; P < 0.10) and total time per breath (5.11 +/- 1.08 to 6.54 +/- 0.82 s; P < 0.05). We conclude that background vagal C-fiber activity exerts an inhibitory effect on tidal volume and an excitatory effect on breathing frequency.