Chiral discrimination of amines by anisotropic NMR parameters using chiral polyacrylamide‐based gels
Chiral discrimination of amines by anisotropic NMR parameters using chiral polyacrylamide‐based gels
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DOI：
10.1002/mrc.3886
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发表时间：
2012-12
影响因子：
2
通讯作者：
Manuel Schmidt;Han Sun;A. Leonov;C. Griesinger;U. Reinscheid
中科院分区：
文献类型：
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作者：
Manuel Schmidt;Han Sun;A. Leonov;C. Griesinger;U. Reinscheid
以二甲基亚砜、甲醇和水为溶剂，合成了一种新型手性配向介质。因为凝胶的两种对映体都是可用的，所以可以对映体区分天然产物，例如天然存在的单一对映体的士的宁盐酸盐。通过拉伸和约束两种方法实现各向异性，可以调节取向度，使指向矢由水平变为垂直。这增加了适用性。三种化合物对映体歧视的基础上残留的偶极耦合数据：盐酸甲氟喹，盐酸士的宁，盐酸薄荷胺。版权所有© 2012约翰威利父子有限公司.
A new chiral alignment medium for dimethyl sulfoxide, methanol, and water as solvents was developed. Because both enantiomers of the gel are available, it is possible to enantiodiscriminate natural products such as strychnine HCl that naturally occurs as single enantiomer. With the two methods of achieving anisotropy, namely stretching and confinement, the degree of alignment can be adjusted, and the director changed from horizontal to vertical. This increases the applicability. Three compounds were enantiodiscriminated on the basis of residual dipolar coupling data: mefloquine HCl, strychnine HCl, and menthylamine HCl. Copyright © 2012 John Wiley & Sons, Ltd.