Telomere maintenance mechanisms and cellular immortalization
Telomere maintenance mechanisms and cellular immortalization
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DOI：
10.1016/s0959-437x(99)80014-8
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发表时间：
1999-02-01
影响因子：
4
通讯作者：
Reddel, RR
中科院分区：
文献类型：
--
作者：
Colgin, LM;Reddel, RR
永生细胞群体能够无限增殖。永生化与正常体细胞中补偿伴随细胞分裂的端粒缩短的过程的激活有关。在许多永生细胞系中，端粒的维持是由核糖核蛋白酶复合体端粒酶的作用提供的。一些永生细胞株的端粒酶活性水平很低或检测不到，有证据表明这些细胞通过另一种机制维持其端粒。
Immortal cell populations are able to proliferate indefinitely. Immortalization is associated with activation of processes that compensate for the telomeric shortening that accompanies cell division in normal somatic cells. In many immortal cell lines, telomere maintenance is provided by the action of the ribonucleoprotein enzyme complex, telomerase. Some immortal cell lines have undetectable or very low levels of telomerase activity and there is evidence that these cells maintain their telomeres by an alternative mechanism.