The relationship between episodic long-term memory and white matter integrity in normal aging
The relationship between episodic long-term memory and white matter integrity in normal aging
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DOI：
10.1016/j.neuropsychologia.2009.08.018
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发表时间：
2010-01-01
期刊：
影响因子：
2.6
通讯作者：
Morris, R. G.
中科院分区：
文献类型：
--
作者：
Charlton, R. A.;Barrick, T. R.;Morris, R. G.
已有研究提出，在正常衰老过程中，情景长时记忆(LTM)下降，可能受白质网络破坏的影响。在GENIE研究中，104名年龄在50-90岁的健康成年人对此进行了探索；使用扩散张量成像(DTI)对大片感兴趣区域的白质完整性进行了评估，并对白质高信号(WMH)、归一化脑和海马体体积进行了额外测量。对LTM的执行功能、工作记忆和信息加工速度进行比较。LTM与DTI、WMH及全脑体积显著相关，与海马体积无相关性。使用线性回归，只有DTI测量解释了LTM的差异(约19%)；中介分析探索了其他认知功能在多大程度上调节DTI变化和记忆之间的联系。结果表明，正常衰老时LTM表现的降低与依赖于支持情节记忆的白质通路的分布式网络的完整性降低有关。(C)2009爱思唯尔有限公司。保留所有权利。
It has been proposed that episodic long-term memory (LTM) declines in normal aging and maybe affected by disruption of white matter networks. This was explored in 104 healthy adults aged 50-90 years in the GENIE study; white matter integrity was assessed using diffusion tensor imaging (DTI) in large regions of interest, with additional measures of white matter hyperintensities (WMH), normalized brain and hippocampal volumes. LTM was compared with executive function, working memory and information processing speed. LTM correlated significantly with DTI, WMH and whole brain volume, but not with hippocampal volume. Using linear regression, only DTI measures explained the variance (approximately 19%) in LTM; mediational analyses explored the extent to which other cognitive functions mediate the association between DTI changes and memory. The results suggest that reduced LTM performance in normal aging is related to reduced integrity of a distributed network dependent on white matter pathways supporting episodic memory. (C) 2009 Elsevier Ltd. All rights reserved.