Hacking mechanical memory
Hacking mechanical memory
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黑客机械记忆
DOI：
10.1016/j.bpj.2023.03.012
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发表时间：
2023
影响因子：
3.4
通讯作者：
Eyckmans, Jeroen
中科院分区：
文献类型：
--
作者：
Eyckmans, Jeroen
自体软骨细胞植入（ACI）是一种用于治疗关节软骨缺陷的外科手术。它涉及从患者体内取出健康的软骨细胞（称为软骨细胞），在实验室中培养数周，然后将其重新植入患者的关节中以再生受损的软骨（1）。尽管ACI被认为是一种有前途的软骨修复技术，但在传统组织培养血管中扩增原代软骨细胞会导致软骨形成表型的不可逆丧失和纤维化表型的出现（2）。这种被称为软骨细胞去分化的现象阻碍了ACI在患者中的临床转化。在本期的《生物物理学杂志》中，Scott，Neu及其同事的一项研究（3）提供了新的见解，即在坚硬的基质上培养软骨细胞如何导致染色质结构的变化和伴随的软骨细胞表型的丧失，这可以通过染色质修饰抑制剂的治疗来部分预防。
Autologous chondrocyte implantation (ACI) is a surgical procedure used to treat cartilage defects in articular joints. It involves removing healthy cartilage cells called chondrocytes from a patient, cultivating them in a laboratory for several weeks, and then reimplanting them into the patient’s joint to regenerate the damaged cartilage (1). Although ACI has been heralded as a promising technique for cartilage repair, expanding primary chondrocytes in conventional tissue culture vessels results in the irreversible loss of the chondrogenic phenotype and the emergence of a fibrotic one (2). This phenomenon, known as chondrocyte dedifferentiation, has hindered the clinical translation of ACI in patients. In this issue of Biophysical Journal, a study from Scott, Neu, and colleagues (3) provides new insights into how culturing chondrocytes on stiff substrates leads to changes in chromatin architecture and concomitant loss of the chondrocyte phenotype, which can be partially prevented by treatment with chromatin modifying inhibitors.