A NEW TECHNIQUE FOR THE INVESTIGATION OF SOME ANALGESIC DRUGS ON A REFLEXIVE BEHAVIOR IN THE RAT
A NEW TECHNIQUE FOR THE INVESTIGATION OF SOME ANALGESIC DRUGS ON A REFLEXIVE BEHAVIOR IN THE RAT
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DOI：
10.1007/bf00404119
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发表时间：
1961-01-01
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影响因子：
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通讯作者：
EVANS, WO
中科院分区：
文献类型：
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作者：
EVANS, WO
在对大鼠足部进行不同强度的电击以引发两种可区分的反射反应的情况下测试了一系列镇痛和精神药物的镇痛作用：低电击值时的“退缩”反应和高电击值时的“跳跃”反应，通过使用改进的极限方法，获得了两种反应的可靠阈值。氯丙嗪，奋乃静，吗啡，可待因，研究发现，纳洛啡和乙酰水杨酸盐可提高“跳跃”阈值，但对“退缩”阈值几乎没有影响。发现 PIH、JB 835、异丙烟肼、利血平、丁苯那嗪和安非他明对“跳跃”或“退缩”阈值没有影响。发现安非他明和可待因的组合可产生协同增效作用。吗啡和纳洛啡的组合被发现会产生拮抗作用。根据比彻的假设，即药物的镇痛作用是由于动物对疼痛反应的情绪成分减少，以及脑胺变化与镇痛作用的关系，对结果进行了讨论。
The analgetic action of a series of analgesic and psychotropic agents was tested in a situation in which variable intensities of electric shock to a rat's feet were used to elicit two distinguishable reflexive responses: a “flinching” response at low shock values, and a “jumping” response at higher shock values,By using a modified method of limits, reliable threshold for the two responses were obtained.Chlorpromazine, perphenazine, morphine, codeine, nalorphine and acetylsalicylate were found to raise the threshold to “jump”, but had little or no effect on the threshold to “flinch”.PIH, JB 835, iproniazid, reserpine, tetrabenazine, and amphetamine were found to have no effect on either the “jump” or the “flinch” thresholds.A combination of amphetamine and codeine was found to produce a synergistic potentiation. A combination of morphine and nalorphine was found to produce an antagonism.The results were discussed in terms ofBeecher's hypothesis that the analgetic action of drugs is due to a diminution of the emotional components of an animal's reaction to pain and in terms of the relationship of brain amine change to analgetic action.