Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study
Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study
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DOI：
10.1258/0969141054855300
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Gulbis, A
中科院分区：
文献类型：
--
作者：
Kafando, E;Sawadogo, M;Gulbis, A
目的：为了确定镰状细胞疾病（SCD）的发病率和新生儿筛查计划在瓦加杜古的可行性。方法：在2000年，2003年和2004年，2341脐带血样本中获得的5个妇产科医院在瓦加杜古SCD使用等电聚焦技术进行了筛选。结果：SCD的发病率为1：57，14例为血红蛋白（Hb）S纯合子，27例为HbSC复合杂合子。32例新生儿为HbC纯合子。HbC性状的发生率为1：6; HbS性状的发生率为1：14。一个集中的实验室新生儿筛查的SCDs established.Conclusions：SCDs应被视为一个重大的公共卫生问题，在瓦加杜古。应实施新生儿筛查方案，但要行之有效，就需要采取适合当地情况的战略。
Objectives: To determine the incidence of sickle cell disorders (SCDs) and the feasibility of a neonatal screening programme in Ouagadougou.Methods: During 2000, 2003 and 2004, 2341 cord blood samples obtained in five maternity hospitals in Ouagadougou were screened for SCDs using an isoelectric focusing technique. The feasibility of a neonatal screening programme was evaluated.Results: The incidence of SCD was 1:57; 14 neonates were homozygous for haemoglobin (Hb)S and 27 were compound heterozygotes for HbSC. Thirty-two neonates were homozygous for HbC. The incidence of the HbC trait was 1 :6; incidence of the HbS trait was 1:14. A centralized laboratory for neonatal screening of SCDs was established.Conclusions: SCDs should be considered a major public health problem in Ouagadougou. A neonatal screening programme should be implemented, but to be effective it requires strategies adapted to the local situation.