Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
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DOI：
10.1631/jzus.b2000022
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Jian-an Wang
中科院分区：
文献类型：
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作者：
Hai-Qiong Zheng;Jiabing Rong;Feiming Ye;Yinchuan Xu;Hong Lu;Jian-an Wang
Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β-aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.
