Do enteric neurons make hypocretin?
Do enteric neurons make hypocretin?
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DOI：
10.1016/j.regpep.2007.11.006
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发表时间：
2008-04-10
影响因子：
--
通讯作者：
Scammell, Thomas E.
中科院分区：
文献类型：
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作者：
Baumann, Christian R.;Clark, Erika L.;Scammell, Thomas E.
下视丘素（食欲素）是由下丘脑神经元产生的促醒神经肽。这些产生下丘脑泌素的细胞在嗜睡症患者中丢失，可能是由于自身免疫攻击。先前的研究描述了肠神经系统中的下丘脑泌素神经元，这些细胞可能是自身免疫过程的另一个靶点。我们试图确定是否肠下丘脑泌素神经元在发作性睡眠受试者中丢失。即使我们尝试了几种方法（包括整体安装，切片组织，用秋水仙碱预处理小鼠，以及使用各种初级抗血清），我们也无法识别从小鼠或正常人受试者收集的肠神经组织中的下丘脑泌素产生细胞。这些结果引起了人们对肠神经元是否产生下丘脑泌素的怀疑。(C)2007 Elsevier B.V.保留所有权利。
Hypocretins (orexins) are wake-promoting neuropeptides produced by hypothalamic neurons. These hypocretin-producing cells are lost in people with narcolepsy, possibly due to an autoimmune attack. Prior studies described hypocretin neurons in the enteric nervous system, and these cells could be an additional target of an autoimmune process. We sought to determine whether enteric hypocretin neurons are lost in narcoleptic subjects. Even though we tried several methods (including whole mounts, sectioned tissue, pre-treatment of mice with colchicine, and the use of various primary antisera), we could not identify hypocretin-producing cells in enteric nervous tissue collected from mice or normal human subjects. These results raise doubts about whether enteric neurons produce hypocretin., (C) 2007 Elsevier B.V. All rights reserved.