Sodium methyldithiocarbamate causes thymic atrophy by an indirect mechanism of corticosterone up-regulation.
Sodium methyldithiocarbamate causes thymic atrophy by an indirect mechanism of corticosterone up-regulation.
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甲基二硫代氨基甲酸钠通过皮质酮上调的间接机制引起胸腺萎缩。
DOI：
10.1080/15476910591006673
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发表时间：
2005
影响因子：
3.3
通讯作者：
Pruett,StephenB
中科院分区：
文献类型：
--
作者：
Myers,LPeyton;Fan,Ruping;Zheng,Qiang;Pruett,StephenB
Sodium methyldithiocarbamate (SMD) is an agricultural fumigant-type pesticide commonly used as a pre-plant biocide. SMD is currently listed by the US Environmental Protection Agency (EPA) as the third most commonly used conventional pesticide. Previously, SMD has been shown to be immunotoxic in mice. Initial immunotoxicological studies indicated that thymocytes are major targets of SMD or its breakdown products in mice. The purpose of the present study was to determine if this effect was mediated by an SMD-induced stress response. The decrease in thymus weight correlated to a decrease in all thymocyte subpopulations. However, as seen in earlier studies, the double positive (CD4+CD8+) thymocyte subpopulation was more selectively decreased than the other subpopulations. The double negative (CD4−CD8−) and single positive (CD4+CD8−or CD4−CD8+) thymocyte subpopulations decreased in absolute numbers while increasing in percentage of the remaining cells in the thymus after SMD intoxication. In the current study, SMD caused an increase in serum corticosterone, a stress-related hormone. Blocking corticosterone either by 1) adrenalectomy or by 2) chemically blocking synthesis of nascent corticosterone in adrenal-competent animals abrogated the thymocyte atrophy caused by SMD. However, an additional stressor (restraint) did not act additively or synergistically to increase atrophy. Therefore, it is likely that SMD causes thymic atrophy by increasing serum corticosterone.
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影响因子：
15.9
作者：
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DOI：
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影响因子：
11.1
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DOI：
10.1016/s0021-9258(18)34459-4
发表时间：
1982-07
期刊：
The Journal of biological chemistry
影响因子：
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DOI：
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发表时间：
1980
期刊：
Biochemical and Biophysical Research Communications - BBRC
影响因子：
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作者：
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影响因子：
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作者：
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