Deoxystreptamine dimers bind to RNA hairpin loops.
Deoxystreptamine dimers bind to RNA hairpin loops.
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脱氧链霉胺二聚体与 RNA 发夹环结合。
DOI：
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发表时间：
2004
影响因子：
15
通讯作者：
P. Hergenrother
中科院分区：
文献类型：
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作者：
Xianjun Liu;J. Thomas;P. Hergenrother
众所周知，RNA在关键的细胞功能中具有多种作用。因此，rna结合小分子作为治疗剂和细胞探针具有很大的潜力。不幸的是，RNA可以采用的多个二级结构给RNA-小分子结合的一般范例的发展带来了困难。特别是，标准的RNA结合化合物，如氨基糖苷，通常不结合RNA发夹环，这是一个广泛和至关重要的二级结构基序。在这篇论文中，我们报道了脱氧链胺二聚体与RNA发夹环结合的亲和力与RNA-氨基糖苷相互作用的亲和力相匹配。
RNA is known to have multiple roles in critical cellular functions. Thus, there is great potential for RNA-binding small molecules as both therapeutic agents and cellular probes. Unfortunately, the multiple secondary structures that RNA can adopt have caused difficulty in the development of a general paradigm for RNA-small molecule binding. In particular, the standard RNA-binding compounds such as aminoglycosides do not generally bind RNA hairpin loops, a widespread and vitally important secondary structural motif. In this manuscript we report that dimers of deoxystreptamine bind to RNA hairpin loops with affinities rivaling that of RNA-aminoglycoside interactions.