Histopathology of celiac disease.
Histopathology of celiac disease.
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DOI：
10.1016/j.giec.2012.07.001
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发表时间：
2012-10-01
影响因子：
--
通讯作者：
Bhagat, Govind
中科院分区：
文献类型：
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作者：
Bao, Fei;Bhagat, Govind
小肠活检仍然是诊断乳糜泻（CD）的金标准。绒毛萎缩背景下的上皮内淋巴细胞增多被认为是CD的特征性组织学发现。然而，研究还表明，在没有绒毛萎缩的情况下检测到上皮内淋巴细胞增多症对CD不是特异性的，在其他小肠疾病中也有记录。本综述总结了关键方面的组织病理学评估，影响的网站和数量的小肠活检样本的诊断，旧的和新出现的分类，标准化的病理学报告的CD诊断工作的好处。
Small bowel biopsy remains the gold standard for diagnosing celiac disease (CD). Intraepithelial lymphocytosis in the context of villous atrophy is considered a characteristic histologic finding of CD. However, studies have also indicated that the detection of intraepithelial lymphocytosis in the absence of villous atrophy is not specific for CD, having been documented in other small intestinal disorders. This review summarizes key aspects regarding the histopathologic assessment, impact of the site and number of small bowel biopsy samples on diagnosis, old and emerging classifications, and benefit of standardized pathology report in the diagnostic workup of CD.