Severity of pulmonary involvement and 18F-FDG PET activity in sarcoidosis
Severity of pulmonary involvement and 18F-FDG PET activity in sarcoidosis
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DOI：
10.1016/j.rmed.2012.11.011
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发表时间：
2013-03-01
影响因子：
4.3
通讯作者：
Drent, Marjolein
中科院分区：
文献类型：
--
作者：
Mostard, Remy L. M.;Verschakelen, Johny A.;Drent, Marjolein
背景：评估炎症活动对于持续症状性结节病患者的治疗很有用。 F-18-FDG PET (PET) 已被证明是评估结节病炎症活动的敏感技术。本研究的目的是评估持续症状性结节病患者肺部受累的严重程度是否与 PET 活动相关。方法：在 5 年的时间里，从 95 名持续性致残症状的结节病患者的病历中收集了相关临床数据，包括实验室和肺功能测试结果，这些患者接受了 PET 和 HRCT。 HRCT 扫描使用半定量评分系统和 PET 结果分别分类为阳性或阴性。结果：77/95 名患者的 PET 呈阳性，其中 56 名患者表现出肺部 PET 阳性。与肺部 PET 结果阴性的患者 (n = 39；3.0 +/- 2.9；p
Background: Assessing inflammatory activity is useful in the management of persistent symptomatic sarcoidosis patients. F-18-FDG PET (PET) has been shown to be a sensitive technique to assess inflammatory activity in sarcoidosis. The aim of this study was to evaluate whether the severity of pulmonary involvement is associated with PET activity in persistent symptomatic sarcoidosis patients.Methods: Over a 5-year period, relevant clinical data including laboratory and lung function test results were gathered from the medical records of 95 sarcoidosis patients with persistent disabling symptoms who underwent both a PET and HRCT. HRCT scans were classified using a semiquantitative scoring system and PET findings as positive or negative, respectively.Results: PET was positive in 77/95 patients, of whom 56 demonstrated pulmonary PET-positivity. HRCT scores were high (7.1 +/- 3.6) in patients with positive pulmonary PET findings (n = 56) compared to patients with negative pulmonary PET findings (n = 39; 3.0 +/- 2.9; p