ABO and Rh blood groups distribution in patients with endometriosis
ABO and Rh blood groups distribution in patients with endometriosis
复制标题
DOI：
10.1007/s00404-009-1031-2
复制
发表时间：
2009-12-01
影响因子：
2.6
通讯作者：
Arici, Aydin
中科院分区：
文献类型：
--
作者：
Matalliotakis, Ioannis;Cakmak, Hakan;Arici, Aydin
本研究的目的有两个：第一，证明子宫内膜异位症、ABO血型和恒河因子之间的关联，第二，显示ABO血型和子宫内膜异位症分期的潜在相关性。方法对耶鲁大学附属医院231例子宫内膜异位症患者和166例未患子宫内膜异位症的不孕症患者进行回顾性分析。所有病例均经腹腔镜诊断，并按标准技术测定ABO血型和恒河因子。子宫内膜异位症患者按分期分为两组：1组ⅰ、ⅱ期124例，2组ⅲ、ⅳ期107例。统计学方法采用chi(2)和比值比（95% CI）。结果子宫内膜异位症患者与非子宫内膜异位症患者的ABO、Rh血型鉴定分布差异有统计学意义[chi(2) = 26.27, P < 0.001]；chi(2) = 18.71, （P < 0.001）。子宫内膜异位症患者A型血较多，O型血较少。子宫内膜异位症和A血型女性的总风险为2.89 （95% CI, 1.85-4.52）。子宫内膜异位症患者ABO、Rh血型根据病情轻重无明显差异。结论a血型的子宫内膜异位症患者发生子宫内膜异位症的风险增加2.9倍。血型在子宫内膜异位症发展中的作用仍有待确定。
Background The aim of this investigation was twofold: first, to demonstrate an association between endometriosis, ABO blood groups and Rhesus factor and, second, to show potential correlation of ABO blood group and stages of endometriosis.Methods Two hundred and thirty-one women with endometriosis and 166 infertile women without endometriosis were studied retrospectively at the Yale University Hospital. All the cases were diagnosed by laparoscopy and in all of them ABO blood groups and Rhesus factor were determined by standard techniques. Women with endometriosis were divided into two groups according to the stage: Group 1 included 124 cases with stages I and II, and Group 2, 107 women with stages III and IV. Statistical methods included chi(2) and odds ratios (95% CI).Results The identified distribution of ABO and Rh blood groups in women with endometriosis differed significantly from that of the women without endometriosis [chi(2) = 26.27, (P < 0.001); chi(2) = 18.71, (P < 0.001), respectively]. The blood group A was more predominant in women with endometriosis, while blood group O was less predominant. The overall risk of women with endometriosis and A blood group was 2.89 (95% CI, 1.85-4.52). No significant difference was detected in ABO and Rh blood groups in women with endometriosis according to the severity of disease.Conclusion Women with endometriosis have a 2.9-fold increased risk in the A blood group distribution. The role of blood groups in the development of endometriosis remains to be determined.