Validation of the Pancreas Donor Risk Index for use in a UK population
Validation of the Pancreas Donor Risk Index for use in a UK population
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DOI：
10.1111/tri.12563
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发表时间：
2015-09-01
影响因子：
3.1
通讯作者：
Vaidya, Anil
中科院分区：
文献类型：
--
作者：
Mittal, Shruti;Lee, Fang Jann;Vaidya, Anil
Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P=0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.
