Time to initial cancer treatment in the United States and association with survival over time: An observational study
Time to initial cancer treatment in the United States and association with survival over time: An observational study
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DOI：
10.1371/journal.pone.0213209
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发表时间：
2019-03-01
期刊：
影响因子：
3.7
通讯作者：
Bolwell, Brian J.
中科院分区：
文献类型：
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作者：
Khorana, Alok A.;Tullio, Katherine;Bolwell, Brian J.
背景新癌症诊断的治疗开始时间（TTI）延迟会导致患者痛苦，并可能对结果产生不利影响。我们调查的趋势TTI常见的实体瘤治疗的治愈意图，增加TTI的决定因素和与整体survival.Methods和findingsWe利用前瞻性数据从国家癌症数据库为新诊断的美国早期乳腺癌，前列腺癌，肺癌，结直肠癌，肾癌和胰腺癌患者从2004年至2013年。TTI定义为从诊断到首次治疗（手术、全身或放射治疗）的天数。采用负二项回归和考克斯比例风险模型进行分析。3，672，561例患者的研究人群包括乳腺癌（N = 1，368，024）、前列腺癌（N = 944，246）、结直肠癌（N = 662，094）、非小细胞肺癌（N = 363，863）、肾癌（N = 262，915）和胰腺癌（N = 71，419）。中位TTI从21天增加到29天（P
BackgroundDelays in time to treatment initiation (TTI) for new cancer diagnoses cause patient distress and may adversely affect outcomes. We investigated trends in TTI for common solid tumors treated with curative intent, determinants of increased TTI and association with overall survival.Methods and findingsWe utilized prospective data from the National Cancer Database for newly diagnosed United States patients with early-stage breast, prostate, lung, colorectal, renal and pancreas cancers from 2004-13. TTI was defined as days from diagnosis to first treatment (surgery, systemic or radiation therapy). Negative binomial regression and Cox proportional hazard models were used for analysis. The study population of 3,672,561 patients included breast (N = 1,368,024), prostate (N = 944,246), colorectal (N = 662,094), non-small cell lung (N = 363,863), renal (N = 262,915) and pancreas (N = 71,419) cancers. Median TTI increased from 21 to 29 days (P