Optical coherence tomography for ultrahigh resolution in vivo imaging
Optical coherence tomography for ultrahigh resolution in vivo imaging
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DOI：
10.1038/nbt892
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发表时间：
2003-11-01
影响因子：
46.9
通讯作者：
Fujimoto, JG
中科院分区：
文献类型：
--
作者：
Fujimoto, JG
光学相干断层扫描（OCT）是一种新兴的生物医学光学成像技术，可对生物系统中的微观结构进行高分辨率横截面断层扫描成像。 OCT 可以实现 1-15 μm 的图像分辨率，比标准超声精细一到两个数量级。 OCT 的图像穿透深度由光学散射决定，在组织中可达 2-3 毫米。 OCT 用作“光学活检”的一种，可提供微米级组织结构的横截面图像。它是一种很有前途的成像技术，因为它可以原位实时提供组织图像，无需切除和处理标本。
Optical coherence tomography (OCT) is an emerging biomedical optical imaging technique that performs high-resolution, cross-sectional tomographic imaging of microstructure in biological systems. OCT can achieve image resolutions of 1-15 mum, one to two orders of magnitude finer than standard ultrasound. The image penetration depth of OCT is determined by the optical scattering and is up to 2-3 mm in tissue. OCT functions as a type of 'optical biopsy' to provide cross-sectional images of tissue structure on the micron scale. It is a promising imaging technology because it can provide images of tissue in situ and in real time, without the need for excision and processing of specimens.