Transition metal substituted sandwich-type polyoxometalates with a strong metal-C (imidazole) bond as anticancer agents
Transition metal substituted sandwich-type polyoxometalates with a strong metal-C (imidazole) bond as anticancer agents
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具有强金属-C（咪唑）键的过渡金属取代夹心型多金属氧酸盐作为抗癌剂
DOI：
10.1039/c8cc07884j
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发表时间：
2019
影响因子：
4.9
通讯作者：
Ni Lubin
中科院分区：
文献类型：
--
作者：
Zhao Hongxia;Tao Li;Zhang Fengmin;Zhang Ying;Liu Yanqing;Xu Hongjie;Diao Guowang;Ni Lubin
以四方簇合物[Na2Sb8W36O132(H2O)4]22−(Sb8W36)为前驱体合成了两种新型夹心型多金属氧酸盐{Na0.7M5.3(H2O)2(Imi)2(Himi)(SbW9O33)2}6−(M=NiII(1)，CoII(2)，imi=咪唑)。化合物1对胃癌细胞具有较强的细胞毒作用，其机制是使细胞周期停滞在S期，诱导细胞凋亡。
Two novel sandwich-type polyoxometalates {Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2}6− (M = NiII (1), CoII (2), imi = imidazole) containing a strong M–Cimi bond were synthesized by a tetragonal cluster [Na2Sb8W36O132(H2O)4]22− {Sb8W36} precursor. Compound 1 was highly cytotoxic against gastric cancer cells by arresting the cell cycle in the S-phase and inducing cell apoptosis.