Dexamethasone suppression test in alcoholism
Dexamethasone suppression test in alcoholism
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酒精中毒的地塞米松抑制试验
DOI：
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发表时间：
1984
影响因子：
6.7
通讯作者：
A. Coppen
中科院分区：
文献类型：
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作者：
M. Abou‐Saleh;J. Merry;A. Coppen
摘要：应用地塞米松抑制试验（DST）研究了酒精患者的下丘脑-垂体-肾上腺功能。对72例戒酒3 - 6周的患者进行了研究。8例脱毒患者与79例对照进行比较。戒酒3 - 6周后，酒精患者DST结果异常的发生率（28%）明显高于对照组（11%）。接受排毒治疗的患者DST结果异常的发生率更高（62%）。在这些患者中，异常的DST状态与抑郁症的存在无关，但与肝功能异常有关。据推测，酒精患者的异常DST反应不是抑郁症的诊断，而可能与酒精对肝脏代谢或下丘脑-垂体-肾上腺功能或两者的影响有关。
ABSTRACT– The hypothalamic‐pituitary‐adrenal function was investigated in alcoholic patients using the dexamethasone suppression test (DST). Seventy‐two patients were studied when they had been abstinent from alcohol for 3 to 6 weeks. Eight patients undergoing detoxification and 79 control subjects were investigated for comparison. Alcoholic patients after a 3‐ to 6‐week abstinence period showed significantly higher prevalence of abnormal DST results (28 %) than control subjects (11 %). Patients undergoing detoxification showed even a higher prevalence of abnormal DST results (62 %). Abnormal DST status was not associated with the presence of depression in these patients but was associated with abnormal liver function. It is supposed that abnormal DST responses in alcoholic patients are not diagnostic of depression but appear to be related to effects of alcohol either on liver metabolism or on the hypothalamic‐pituitary‐adrenal function or both.
影响因子：
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作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
通讯作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young