Vestibular stimulation-induced facilitation of cervical premotoneuronal systems in humans.
Vestibular stimulation-induced facilitation of cervical premotoneuronal systems in humans.
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DOI：
10.1371/journal.pone.0175131
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Ohki Y
中科院分区：
文献类型：
--
作者：
Suzuki S;Nakajima T;Irie S;Ariyasu R;Komiyama T;Ohki Y
目前尚不清楚来自前庭系统的下行输入如何影响人类颈部中间神经元的兴奋性。为了阐明这一点，我们研究了前庭电流刺激(GVS)对锥体束和外周神经联合刺激诱发的运动诱发电位(MEPs)空间易化的影响。为了评估空间易化，记录了健康受试者的二头肌肌电。分别或同时给予对侧初级运动皮质经颅磁刺激(TMS)和同侧腕部尺神经电刺激，刺激间隔10ms(TMS后)。阴阳极GVS随机给予TMS和/或尺神经刺激。TMS和尺神经刺激联合刺激对BB MEP的促进作用明显大于TMS和尺神经刺激分别引起的反应的代数和(即空间易化)。GVS与MEP联合刺激时，MEP易化性显著增强(p<；0.01)。阴阳极GVS与阴阳极GVS之间无显著差异。此外，单运动单位记录显示，联合刺激时刺激周围时间直方图中的短潜伏期兴奋性峰值随着GVS的增加而显著增加。短刺激间期(即10ms)联合刺激的空间易化效应表明，易化发生在颈髓的运动神经元前水平。因此，目前的研究结果表明，GVS促进了颈部中间神经元系统的整合，该系统整合了锥体束和周围神经的输入，并兴奋了支配上臂肌肉的运动神经元。
It is unclear how descending inputs from the vestibular system affect the excitability of cervical interneurons in humans. To elucidate this, we investigated the effects of galvanic vestibular stimulation (GVS) on the spatial facilitation of motor-evoked potentials (MEPs) induced by combined pyramidal tract and peripheral nerve stimulation. To assess the spatial facilitation, electromyograms were recorded from the biceps brachii muscles (BB) of healthy subjects. Transcranial magnetic stimulation (TMS) over the contralateral primary motor cortex and electrical stimulation of the ipsilateral ulnar nerve at the wrist were delivered either separately or together, with interstimulus intervals of 10 ms (TMS behind). Anodal/cathodal GVS was randomly delivered with TMS and/or ulnar nerve stimulation. The combination of TMS and ulnar nerve stimulation facilitated BB MEPs significantly more than the algebraic summation of responses induced separately by TMS and ulnar nerve stimulation (i.e., spatial facilitation). MEP facilitation significantly increased when combined stimulation was delivered with GVS (p < 0.01). No significant differences were found between anodal and cathodal GVS. Furthermore, single motor unit recordings showed that the short-latency excitatory peak in peri-stimulus time histograms during combined stimulation increased significantly with GVS. The spatial facilitatory effects of combined stimulation with short interstimulus intervals (i.e., 10 ms) indicate that facilitation occurred at the premotoneuronal level in the cervical cord. The present findings therefore suggest that GVS facilitates the cervical interneuron system that integrates inputs from the pyramidal tract and peripheral nerves and excites motoneurons innervating the arm muscles.