MECHANISM OF ANTIFOAMING ACTION OF SIMETHICONE
MECHANISM OF ANTIFOAMING ACTION OF SIMETHICONE
复制标题
DOI：
10.1002/jat.2550140311
复制
发表时间：
1994-05-01
影响因子：
3.3
通讯作者：
STRAJNAR, F
中科院分区：
文献类型：
--
作者：
BRECEVIC, L;BOSANKILIBARDA, I;STRAJNAR, F
主要用于治疗肠胃气胀的西甲硅油的抑泡作用机理已被研究。它对含有合成胃液和表面活性物质（阴离子表面活性剂，阳离子表面活性剂，肥皂溶液）的发泡系统的影响通过测量表面张力，泡沫稳定性和初始泡沫密度来定量。西甲硅油对每个检查系统的影响是两种作用组合的结果：泡沫膜中液体的排出和相对厚的液膜的破裂。这些作用的机制可以描述为液体排出，然后通过聚二甲基硅氧烷液滴桥接液膜，在消泡剂中也存在的疏水二氧化硅颗粒的帮助下，导致膜表面破裂和空气逸出。
The mechanism of the foam-inhibiting action of simethicone, mainly used against flatulence, has been studied. Its effect on foaming systems containing synthetic gastric juice and a surface-active substance (anionic surfactant, cationic surfactant, soap solution) was quantitated by measuring the surface tension, foam stability and initial foam density. The effect of simethicone on each of the examined systems was the result of the combination of two actions: the drainage of liquid from foam films and the rupture of relatively thick liquid films. The mechanism of these actions may be described as the liquid drainage followed by bridging of the liquid film by polydimethylsiloxane droplets, helped by hydrophobic silica particles also present in the antifoaming agent, leading to the rupture of the film surface and air escape.