PRODUCTION OF ENDOCARDITIS WITH STAPHYLOCOCCUS-AUREUS AND STREPTOCOCCUS-MITIS IN DOGS WITH AORTIC INSUFFICIENCY
PRODUCTION OF ENDOCARDITIS WITH STAPHYLOCOCCUS-AUREUS AND STREPTOCOCCUS-MITIS IN DOGS WITH AORTIC INSUFFICIENCY
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DOI：
10.1161/01.res.4.3.250
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发表时间：
1956-01-01
影响因子：
20.1
通讯作者：
ALTLAND, PD
中科院分区：
文献类型：
--
作者：
HIGHMAN, B;ROSHE, J;ALTLAND, PD
描述了一种在犬中持续产生心内膜炎的新方法。 15 只狗的主动脉瓣一个或两个冠状尖瓣基部穿孔，导致主动脉瓣关闭不全。手术后 8-159 天开始，狗接受金黄色葡萄球菌或轻链球菌 JH26 (Lancefield D) 肉汤培养物的静脉注射。临床病程和病理表现分别类似于急性和亚急性细菌性心内膜炎。所有 15 只狗均出现瓣膜病变，主要局限于主动脉和二尖瓣小叶的接触面以及邻近区域。给予轻链球菌的狗通常会出现急性弥漫性增殖性肾小球肾炎和局灶性肾小球病变。十只对照狗，包括两只经过假手术的狗，也接受了类似的注射，但没有表现出这样的病变。心脏工作负荷的增加和冠状动脉血流量的相对减少被认为是导致心内膜炎易感性增加的可能重要因素。
A new method for the consistent production of endocarditis in dogs is described. Aortic insufficiency was produced in 15 dogs by perforating the base of one or both coronary cusps of the aortic valve. Beginning 8-159 days after surgery, the dogs received intravenous injections of broth cultures of either S. aureus or S. mitis JH26 (Lancefield D). The clinical course and pathologic picture resembled those of acute and subacute bacterial endocarditis, respectively. All 15 dogs developed valvular lesions, confined largely to the contacting surfaces of the aortic and mitral leaflets and contiguous areas. Dogs given S. mitis often developed an acute diffuse proliferative glomerulonephritis and focal glomerular lesions. Ten control dogs, including 2 with sham operations, were similarly injected and showed no such lesions. An increased cardiac work load and perhaps a relatively diminished coronary blood flow are considered possible important factors contributing to the increased susceptibility to endocarditis.