Spermatozoa as biomarkers for the assessment of human male infertility and genotoxicity
Spermatozoa as biomarkers for the assessment of human male infertility and genotoxicity
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DOI：
10.3109/19396368.2011.637152
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发表时间：
2012-02-01
影响因子：
2.4
通讯作者：
Krawetz, Stephen A.
中科院分区：
文献类型：
--
作者：
Anton, Ester;Krawetz, Stephen A.
建立特定的生物标志物来评估人类男性生育状况是确保男性贡献的适合性，从而支持健康儿童的出生的重要目标。精子被认为是评价生精功能的最佳替代组织。与睾丸细胞不同，精子不需要侵入性程序来获取样本。广泛的精子生物标志物和测试已被描述为有用的精子功能评估。然而，考虑到目前可为此目的开发的分子诊断技术的现状，这些方法似乎有限。在这篇综述中，我们概述了目前用于评估人类男性生育状况的精子生物标志物。将讨论它们作为基因毒性暴露指标的用途。
Establishing specific biomarkers for the assessment of human male fertility status is an important goal to ensure the fitness of the male contribution so as to support the birth of a healthy child. Spermatozoa are considered an optimal surrogate tissue for the evaluation of spermatogenic function. Unlike the cells of the testis, spermatozoa do not require invasive procedures to procure a sample. A broad range of sperm biomarkers and tests have been described as useful for the assessment of the sperm function. However, these approaches appear limited considering the current state of the art of molecular diagnostics that could be developed for this purpose. In this review, we outline the suite of sperm biomarkers that are currently in use to assess human male fertility status. Their use as indicators of genotoxic exposure will be discussed.