THE DIET AND 15-YEAR DEATH RATE IN THE 7 COUNTRIES STUDY
THE DIET AND 15-YEAR DEATH RATE IN THE 7 COUNTRIES STUDY
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DOI：
10.1093/oxfordjournals.aje.a114480
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发表时间：
1986-12-01
影响因子：
5
通讯作者：
TOSHIMA, H
中科院分区：
文献类型：
--
作者：
KEYS, A;MENOTTI, A;TOSHIMA, H
在七国研究的15个队列中，包括11，579名年龄在40-59岁之间并且在进入时“健康”的男性，2，288人在15年内死亡。死亡率在不同的队列之间存在差异。平均年龄、血压、血清胆固醇和吸烟习惯的差异“解释”了46%的全因死亡率差异，80%的冠心病死亡率差异，35%的癌症死亡率差异，45%的中风死亡率差异。死亡率差异与平均相对体重、肥胖和体力活动的队列差异无关。 这些队列的平均饮食不同。死亡率与饱和脂肪酸的平均膳食能量百分比呈正相关，与单不饱和脂肪酸的膳食能量百分比呈负相关，与多不饱和脂肪酸、蛋白质、碳水化合物和酒精的膳食能量百分比无关。所有死亡率均与单不饱和脂肪酸与饱和脂肪酸的比值呈负相关。包括年龄，血压，血清胆固醇和吸烟习惯作为自变量的比率占所有原因死亡率的85%，冠心病96%，癌症55%和中风66%。油酸几乎解释了队列中单不饱和化合物的所有差异。在以橄榄油为主要脂肪的人群中，全因和冠心病死亡率较低。不主张因果关系，但在评估风险时，应考虑群体特征以及群体中的个体特征。
In 15 cohorts of the Seven Countries Study, comprising 11,579 men aged 40-59 years and "healthy" at entry, 2,288 died in 15 years. Death rates differed among cohorts. Differences in mean age, blood pressure, serum cholesterol, and smoking habits "explained" 46% of variance in death rate from all causes, 80% from coronary heart disease, 35% from cancer, and 45% from stroke. Death rate differences were unrelated to cohort differences in mean relative body weight, fatness, and physical activity. The cohorts differed in average diets. Death rates were related positively to average percentage of dietary energy from saturated fatty acids, negatively to dietary energy percentage from monounsaturated fatty acids, and were unrelated to dietary enery percentage from polyunsaturated fatty acids, proteins, carbohydrates, and alcohol. All death rates were negatively related to the ratio of monounsaturated to saturated fatty acids. Inclusion of that ratio with age, blood pressure, serum cholesterol, and smoking habits as independent variables accounted for 85% of variance in rates of deaths from all causes, 96% coronary heart disease, 55% cancer, and 66% stroke. Oleic acid accounted for almost all differences in monounsaturates among cohorts. All-cause and coronary heart disease death rates were low in cohorts with olive oil as the main fat. Causal relationships are not claimed but consideration of characteristics of populations as well as of individuals within populations is urged in evaluating risks.