Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications.
Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications.
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DOI：
10.3390/ijms140611692
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发表时间：
2013-05-31
影响因子：
5.6
通讯作者：
Borlongan CV
中科院分区：
文献类型：
--
作者：
Kim DW;Staples M;Shinozuka K;Pantcheva P;Kang SD;Borlongan CV
华顿氏胶（Wharton's jelly，WJ）是脐带内的一种凝胶状组织，含有成肌纤维细胞样基质细胞。WJ的一个独特的细胞群体，已被认为是显示干细胞表型是间充质基质细胞（MSC）。由于MSC的干细胞性和免疫特性似乎更稳健地表达和功能性，这与胎儿来源的MSC相比更具有可比性，因此认为从“年轻”WJ收获的MSC比从老年成人组织来源（如骨髓或脂肪）分离的干细胞更具增殖性、免疫抑制性和甚至治疗活性。本综述讨论了WJ衍生干细胞的表型特征，治疗应用和实验方案的优化。来源于WJ的MSC显示出有希望的可移植特性，包括易于来源、体外扩增性、分化能力、免疫逃避和免疫调节能力。越来越多的证据表明，WJ来源的干细胞作为可移植细胞具有许多潜在的优点，用于治疗各种疾病（例如，癌症、慢性肝病、心血管疾病、神经、软骨和肌腱损伤）。需要进行更多的研究来将WJ来源的干细胞用于临床应用。
Wharton’s jelly (WJ) is a gelatinous tissue within the umbilical cord that contains myofibroblast-like stromal cells. A unique cell population of WJ that has been suggested as displaying the stemness phenotype is the mesenchymal stromal cells (MSCs). Because MSCs’ stemness and immune properties appear to be more robustly expressed and functional which are more comparable with fetal than adult-derived MSCs, MSCs harvested from the “young” WJ are considered much more proliferative, immunosuppressive, and even therapeutically active stem cells than those isolated from older, adult tissue sources such as the bone marrow or adipose. The present review discusses the phenotypic characteristics, therapeutic applications, and optimization of experimental protocols for WJ-derived stem cells. MSCs derived from WJ display promising transplantable features, including ease of sourcing, in vitro expandability, differentiation abilities, immune-evasion and immune-regulation capacities. Accumulating evidence demonstrates that WJ-derived stem cells possess many potential advantages as transplantable cells for treatment of various diseases (e.g., cancer, chronic liver disease, cardiovascular diseases, nerve, cartilage and tendon injury). Additional studies are warranted to translate the use of WJ-derived stem cells for clinical applications.
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