SENESCENCE AND RENAL VASCULATURE IN NORMAL MAN
SENESCENCE AND RENAL VASCULATURE IN NORMAL MAN
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DOI：
10.1161/01.res.34.3.309
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发表时间：
1974-01-01
影响因子：
20.1
通讯作者：
MERRILL, JP
中科院分区：
文献类型：
--
作者：
HOLLENBERG, NK;ADAMS, DF;MERRILL, JP
应用氙气冲洗技术和肾血流对血管活性物质或钠摄入量改变的反应，研究了207名年龄在17-76岁的正常人肾血管的老化效应。随着年龄的增长，平均血流量、快速成分血流率和流入快速血流(皮质)室的百分比均有非常显著的进行性降低。由于133Xe测量的是单位组织质量的流量，结果表明流量的减少比质量的减少更大--如果流量减少是萎缩的主要原因，这是预期的发现。AGE还减少了由于给予乙酰胆碱或钠负荷而导致的血管扩张；这一发现与固定的血管损伤是一致的。对血管紧张素的反应不受年龄的影响。因此，管壁/管腔厚度比增加和平滑肌萎缩的抵消因素是精确匹配的。这项研究中的发现与基于形态学的早期假说一致，该假说认为在年龄相关的肾脏变化的发展中存在初级血管过程。
The xenon washout technique and the renal blood flow response to vasoactive agents or alterations in sodium intake were used to characterize the effect of aging on the renal vasculature in 207 normal human subjects ranging in age from 17 to 76 years. A highly significant, progressive reduction in the mean blood flow, the rapid-component flow rate, and the percent of flow into the rapid-flow (cortical) compartment accompanied advancing age. Because133Xe measures flow per unit tissue mass, the results indicated a larger reduction in flow than in mass--the anticipated finding if flow reduction is primary in the genesis of atrophy. Age also reduced the vasodilation consequent to administration of acetylcholine or a sodium load; this finding is consistent with a fixed lesion of the vessels. Responses to angiotensin were not modified by age. Thus, offsetting factors of increased ratio of wall to lumen thickness and smooth muscle atrophy are precisely matched. The findings in this study agree with earlier hypotheses based on morphology that suggest a primary vascular process in the development of age-related renal changes.