Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants.
Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants.
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在户外光线下度过的时间与情绪、睡眠和昼夜节律相关的结果相关：一项对超过40万英国生物库参与者的横断面和纵向研究。
DOI：
10.1016/j.jad.2021.08.056
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发表时间：
2021-12-01
影响因子：
6.6
通讯作者：
Cain SW
中科院分区：
文献类型：
--
作者：
Burns AC;Saxena R;Vetter C;Phillips AJK;Lane JM;Cain SW
光线对情绪、睡眠和昼夜节律系统有着强大的影响。人类在一个昼夜分明的环境中进化，但我们的现代环境已经模糊了这种区别。夜间光照的负面影响已经得到了很好的描述。日间光照的重要性还没有得到很好的描述。在这里，我们研究了在白天户外光线下度过的时间与情绪，睡眠和昼夜节律相关结果的横截面和纵向关联。参与者来自英国生物库队列，这是一项针对英国成年人的大型研究（n = 502，000; 37-73岁; 54%为女性）。英国生物银行参与者报告说，他们每天在户外度过的平均时间为2.5个白天小时（IQR = 1.5-3.5小时）。白天在户外每多呆一小时，终生重度抑郁障碍的几率就更低（95%CI OR：0.92 - 0.98），抗抑郁药的使用（OR：0.92-0.98），快感缺乏（OR：0.93-0.96）和情绪低落（OR：0.87-0.90）的频率更低，幸福感更高（OR：1.41-1.48）和神经质更低（发病率比，IRR：0.95-0.96），与人口统计学、生活方式和就业协变量无关。此外，每小时的白天光照与更容易起床（OR：1.46-1.49），更少的疲劳（OR：0.80-0.82），更少的失眠症状（OR：0.94-0.97）和更早的时钟类型（调整后的比值比; OR：0.75-0.77）相关。使用自回归交叉滞后（ARCL）模型来检查基线时户外光照时间与时间点2报告的后期情绪、睡眠和昼夜节律相关结果的纵向相关性。总体而言，纵向关联支持横截面的研究结果，虽然通常具有较小的效应量。未来的研究，检查强度的白天暴露在眼睛的水平是必要的。我们的研究结果表明，低白天光照是情绪，睡眠和昼夜节律相关结果的重要环境风险因素。
Light has powerful effects on mood, sleep, and the circadian system. Humans evolved in an environment with a clear distinction between day and night, but our modern environments have blurred this distinction. Negative effects of light exposure at night have been well characterized. The importance of daytime light exposure has been less well characterized. Here we examine the cross-sectional and longitudinal associations of time spent in daytime outdoor light with mood, sleep, and circadian-related outcomes. Participants were drawn from the UK Biobank cohort, a large study of UK adults (n = 502,000; 37–73 years old; 54% women). UK Biobank participants reported spending a median of 2.5 daylight hours (IQR = 1.5–3.5 h) outdoors per day. Each additional hour spent outdoors during the day was associated with lower odds of lifetime major depressive disorder (95% CI OR:0.92–0.98), antidepressant usage (OR:0.92–0.98), less frequent anhedonia (OR:0.93–0.96) and low mood (OR:0.87–0.90), greater happiness (OR:1.41–1.48) and lower neuroticism (incident rate ratio, IRR:0.95–0.96), independent of demographic, lifestyle, and employment covariates. In addition, each hour of daytime light was associated with greater ease of getting up (OR:1.46–1.49), less frequent tiredness (OR:0.80–0.82), fewer insomnia symptoms (OR:0.94–0.97), and earlier chronotype (adjusted odds ratio; OR:0.75–0.77). Auto-Regressive Cross-Lagged (ARCL) models were used to examine the longitudinal association of time spent in outdoor light at baseline with later mood-, sleep- and circadian-related outcomes reported at time point 2. Overall, longitudinal associations support cross-sectional findings, though generally with smaller effect sizes. Future studies that examine the intensity of daytime light exposure at the ocular level are needed. Our findings suggest that low daytime light exposure is an important environmental risk factor for mood, sleep, and circadian-related outcomes.
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影响因子：
4.7
作者：
Leger, Damien;Bayon, Virginie;Choudat, Dominique
通讯作者：
Choudat, Dominique
DOI：
10.1056/nejmra1802337
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Allada R;Bass J
通讯作者：
Bass J
影响因子：
3.1
作者：
Ancoli-Israel, Sonia;Gehrman, Philip;Levi, Leah
通讯作者：
Levi, Leah
影响因子：
4.6
作者：
Cain SW;McGlashan EM;Vidafar P;Mustafovska J;Curran SPN;Wang X;Mohamed A;Kalavally V;Phillips AJK
通讯作者：
Phillips AJK
影响因子：
30.8
作者：
Bulik-Sullivan B;Finucane HK;Anttila V;Gusev A;Day FR;Loh PR;ReproGen Consortium;Psychiatric Genomics Consortium;Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3;Duncan L;Perry JR;Patterson N;Robinson EB;Daly MJ;Price AL;Neale BM
通讯作者：
Neale BM