Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes.
Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes.
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DOI：
10.2337/dc12-2469
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发表时间：
2013-08
期刊：
影响因子：
16.2
通讯作者：
Genovese S
中科院分区：
文献类型：
--
作者：
Ceriello A;Novials A;Ortega E;Canivell S;La Sala L;Pujadas G;Esposito K;Giugliano D;Genovese S
高血糖和低血糖目前被认为是1型糖尿病心血管疾病的危险因素。急性高血糖和低血糖均诱导内皮功能障碍和炎症，提高氧化应激。胰高血糖素样肽1（GLP-1）具有抗氧化特性，有证据表明它保护内皮功能。评价了1型糖尿病患者急性高血糖和急性低血糖（伴或不伴GLP-1同时输注）对氧化应激（血浆硝基酪氨酸和血浆8-异前列腺素F2 α）、炎症（可溶性细胞间粘附分子-1和白细胞介素-6）和内皮功能障碍的影响。高血糖症和低血糖症均急性诱导氧化应激、炎症和内皮功能障碍。GLP-1显著抵消了这些作用。这些结果表明GLP-1在1型糖尿病的低血糖和高血糖期间具有保护作用。
Hyperglycemia and hypoglycemia currently are considered risk factors for cardiovascular disease in type 1diabetes. Both acute hyperglycemia and hypoglycemia induce endothelial dysfunction and inflammation, raising the oxidative stress. Glucagon-like peptide 1 (GLP-1) has antioxidant properties, and evidence suggests that it protects endothelial function. The effect of both acute hyperglycemia and acute hypoglycemia in type 1 diabetes, with or without the simultaneous infusion of GLP-1, on oxidative stress (plasma nitrotyrosine and plasma 8-iso prostaglandin F2alpha), inflammation (soluble intercellular adhesion molecule-1 and interleukin-6), and endothelial dysfunction has been evaluated. Both hyperglycemia and hypoglycemia acutely induced oxidative stress, inflammation, and endothelial dysfunction. GLP-1 significantly counterbalanced these effects. These results suggest a protective effect of GLP-1 during both hypoglycemia and hyperglycemia in type 1 diabetes.