The sickle cell painful crisis in adults: Phases and objective signs
The sickle cell painful crisis in adults: Phases and objective signs
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DOI：
10.3109/03630269509005824
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发表时间：
1995-01-01
期刊：
影响因子：
1
通讯作者：
Ballas, SK
中科院分区：
文献类型：
--
作者：
Ballas, SK
严重的镰状细胞疼痛危机，需要住院治疗的成年人通常似乎演变沿着四个不同的阶段：前驱，初始，建立和解决。每个阶段可能与某些临床和实验室结果相关。在危机的初始阶段，客观的临床和实验室体征可能不明显，特别是在缺乏可靠的基线稳态数据的情况下。几个临床，血液学，生化和神学的变化出现的危机进展。这一系列事件在这些患者的护理中产生了几个后勤问题。在危机早期缺乏客观的发现通常会阻止医疗保健提供者重复这种测试，并使其中一些人怀疑所讨论的痛苦事件的真实性。因此，病人和他们的护理人员之间可能会产生不信任的气氛。这篇综述将镰状细胞疼痛危机的角度来看，并根据现有的数据在文献中，表明它是一个动态的过程，其特点是在其演变过程中的几个变化。希望这篇综述能消除对疼痛危象的一些误解，阐明其临床过程，并鼓励进一步的研究来回答它提出的问题。
The severe sickle cell painful crisis that requires hospitalization in adults typically seems to evolve along four distinct phases: Prodromal, initial, established, and resolving. Each phase may to be associated with certain clinical and laboratory findings. Objective clinical and laboratory signs may not be evident in the initial phase of the crisis especially in the absence of reliable base line steady state data. Several clinical, hematological, biochemical, and theological changes emerge as the crisis progresses. This sequence of events creates several logistic issues in the care of these patients. The absence of objective findings early in the crisis usually discourages health care providers from repeating such tests and makes some of them suspicious of the authenticity of the painful episode in question. Consequently, an atmosphere of mistrust may develop between the patients and their care providers. This review puts the sickle cell painful crisis in perspective and, based on available data in the literature, shows that it is a dynamic process characterized by several changes during its evolution. It is hoped that this review will dispel some misconceptions about the painful crisis, elucidate its clinical course, and encourage further research to answer the questions it raises.