A control approach for pore size distribution in the bone scaffold based on the hexahedral mesh refinement
A control approach for pore size distribution in the bone scaffold based on the hexahedral mesh refinement
复制标题
基于六面体网格细化的骨支架孔径分布控制方法
DOI：
10.1016/j.cad.2008.09.004
复制
发表时间：
2008-10-01
影响因子：
4.3
通讯作者：
Xi, Juntong
中科院分区：
文献类型：
--
作者：
Cai, Shengyong;Xi, Juntong
组织工程是将这些知识应用于组织的构建或修复。一般来说，工程组织是活细胞和被称为支架的支撑结构的组合。具有复杂结构、孔隙度和孔径的组织支架的建模、设计和制造是组织工程中的一个挑战。本文提出了一种基于六面体网格细化的骨支架孔径分布控制方法。首先，提出了基于有限元法中形状函数的骨支架建模方法。由此可以得到各种各样的大孔形态。然后给出了全六面体单元网格的保角细化算法。最后，提出了一种构建具有确定孔径分布的组织工程骨支架的建模方法。在对全六面体单元网格进行共形精化之前，必须先提供包含多种六面体单元的三维网格。如果需要减少骨支架中的所有孔隙，那就意味着需要对整个六面体网格进行细化。然后，可以通过改变细分参数对实体进行重新划分。如果需要缩小骨骼局部区域的孔隙，则意味着需要对局部区域的3D六面体网格进行细化。基于扫描电镜图像，可以得到正常骨的孔径分布。然后，通过对全六面体单元网格的保角细化，得到确定的六面体尺寸分布，从而生成确定的骨支架孔隙尺寸分布，因为孔隙形态和大小是由各个细分的六面体单元控制的。与超临界流体处理中变化处理参数、多室内结构设计等方法相比，该方法具有易控制性和更高的精度。(c) 2008 Elsevier Ltd.版权所有。
Tissue engineering is the application of that knowledge to the building or repairing of tissues. Generally, engineered tissue is a combination of living cells and a support structure called scaffolds. Modeling, design and fabrication Of tissue scaffold with intricate architecture, porosity and pore size for desired tissue properties presents a challenge in tissue engineering. In this paper, a control approach for pore size distribution in the bone scaffold based on the hexatiedral mesh refinement is presented. Firstly, the bone scaffold modeling approach based on the shape function in the finite element method is provided. The resulting various macroporous morphologies can be obtained. Then conformal refinement algorithm for all-hexahedral element mesh is illustrated. Finally, a modeling approach for constructing tissue engineering (TE) bone scaffold with defined pore size distribution is presented. Before the conformal refinement of all-hexahedral element mesh, a 3D mesh with various hexahedral elements must be provided. If all the pores in the bone scaffold need to be reduced, that means that the whole hexahedral mesh needs to be refined. Then the solid entity can be re-divided with altered subdivision parameters. If the pores in the local regions of bone need to be reduced, that means that 3D hexahedral mesh in the local regions needs to be refined. Based on SEM images, the pore size distribution in the normal bone can be obtained. Then, according to the conformal refinement of all-hexahedral element meshes, defined hexahedral size distribution can be gained, which leads to generate defined pore size distribution in the bone scaffold, for the pore morphology and size are controlled by various subdivided hexahedral elements. Compared to other methods such as varying processing parameters in supercritical fluid processing and multi-interior architecture design, the method proposed in this paper enjoys easy-controllability and higher accuracy. (c) 2008 Elsevier Ltd. All rights reserved.