Predictors of Response Outcomes for Research Recruitment Through a Central Cancer Registry: Evidence From 17 Recruitment Efforts for Population-Based Studies
Predictors of Response Outcomes for Research Recruitment Through a Central Cancer Registry: Evidence From 17 Recruitment Efforts for Population-Based Studies
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DOI：
10.1093/aje/kwz011
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发表时间：
2019-05-01
影响因子：
5
通讯作者：
Sweeney, Carol
中科院分区：
文献类型：
--
作者：
Millar, Morgan M.;Kinney, Anita Y.;Sweeney, Carol
当通过中央癌症登记处招募研究参与者时，高反应分数有助于确保基于人群的代表性。我们进行了多变量混合效应逻辑回归，以确定与犹他州癌症病例联系并获得其合作相关的病例和研究特征，这些数据来自犹他州癌症登记处进行的17项独特招募工作（2007-2016年）代表下列研究：犹他州一项基于人群的儿童癌症幸存者队列研究：前列腺癌手术和放疗的疗效比较分析（CEASAR研究）、青少年和青年癌症随访护理的成本和效益、头颈癌易感基因外显子组测序研究、慢性淋巴细胞白血病遗传流行病学、偏远家族性结直肠癌风险评估和咨询的影响（Family CARE Project）、家族性结肠癌基因大规模平行测序、甲状腺髓样癌（MTC）监测研究、骨肉瘤监测研究、前列腺癌结局研究、癌症遗传风险教育和评估项目（REACH项目），高风险乳腺癌基因谱系中共享基因组片段分析和肿瘤亚型的研究，定位多发性骨髓瘤基因的共享基因组片段分析研究。与接触几率较低相关的特征包括西班牙裔（比值比（OR）= 0.34，95%置信区间（CI）：0.27，0.41）、非白人（OR = 0.46，95% CI：0.35，0.60）和接触时年龄较小。确诊后的年数与接触次数呈负相关。非白人种族和年龄>= 60岁的合作几率较低。合作几率较低的研究特征包括纵向设计（OR = 0.50，95%CI：0.41，0.61）和研究手册（OR = 0.70，95%CI：0.54，0.90）。合作几率的增加与问卷调查（OR = 3.19，95% CI：1.54，6.59）、邮票（OR = 1.60，95% CI：1.21，2.12）和激励措施（OR = 1.62，95% CI：1.02，2.57）有关。在第一次接触后无反应的病例中，在随后的接触前超过10天时，最终反应的几率较低（OR = 0.71，95%CI：0.59，0.85）。获得高缓解具有挑战性，但本分析中确定的研究特征支持通过中央癌症登记中心招募时获得更好的结果。
When recruiting research participants through central cancer registries, high response fractions help ensure population-based representation. We conducted multivariable mixed-effects logistic regression to identify case and study characteristics associated with making contact with and obtaining cooperation of Utah cancer cases using data from 17 unique recruitment efforts undertaken by the Utah Cancer Registry (2007-2016) on behalf of the following studies: A Population-Based Childhood Cancer Survivors Cohort Study in Utah, Comparative Effectiveness Analysis of Surgery and Radiation for Prostate Cancer (CEASAR Study), Costs and Benefits of Follow-up Care for Adolescent and Young Adult Cancers, Study of Exome Sequencing for Head and Neck Cancer Susceptibility Genes, Genetic Epidemiology of Chronic Lymphocytic Leukemia, Impact of Remote Familial Colorectal Cancer Risk Assessment and Counseling (Family CARE Project), Massively Parallel Sequencing for Familial Colon Cancer Genes, Medullary Thyroid Carcinoma (MTC) Surveillance Study, Osteosarcoma Surveillance Study, Prostate Cancer Outcomes Study, Risk Education and Assessment for Cancer Heredity Project (REACH Project), Study of Shared Genomic Segment Analysis and Tumor Subtyping in High-Risk Breast-Cancer Gene Pedigrees, Study of Shared Genomic Segment Analysis for Localizing Multiple Myeloma Genes. Characteristics associated with lower odds of contact included Hispanic ethnicity (odds ratio (OR) = 0.34, 95% confidence interval (CI): 0.27, 0.41), nonwhite race (OR = 0.46, 95% CI: 0.35, 0.60), and younger age at contact. Years since diagnosis was inversely associated with making contact. Nonwhite race and age >= 60 years had lower odds of cooperation. Study features with lower odds of cooperation included longitudinal design (OR = 0.50, 95% CI: 0.41, 0.61) and study brochures (OR = 0.70, 95% CI: 0.54, 0.90). Increased odds of cooperation were associated with including a questionnaire (OR = 3.19, 95% CI: 1.54, 6.59), postage stamps (OR = 1.60, 95% CI: 1.21, 2.12), and incentives (OR = 1.62, 95% CI: 1.02, 2.57). Among cases not responding after the first contact, odds of eventual response were lower when >10 days elapsed before subsequent contact (OR = 0.71, 95% CI: 0.59, 0.85). Obtaining high response is challenging, but study features identified in this analysis support better results when recruiting through central cancer registries.