Expression of GOLPH2 is associated with the progression of and poor prognosis in gastric cancer
Expression of GOLPH2 is associated with the progression of and poor prognosis in gastric cancer
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DOI：
10.3892/or.2014.3404
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发表时间：
2014-11-01
期刊：
影响因子：
4.2
通讯作者：
Niu, Daoli
中科院分区：
文献类型：
--
作者：
Liu, Guanglin;Zhang, Yan;Niu, Daoli
高尔基体磷蛋白2（Golgi phosphoprotein 2，GOLPH 2）与多种人类癌症的发生和发展有关。本研究旨在探讨GOLPH2与胃癌进展的关系及其在胃癌中的临床意义。采用免疫组化、定量PCR和Western印迹法检测同一患者的4对原发性胃癌组织和癌旁组织中GOLPH2的表达。此外，GOLPH 2蛋白的表达在10个正常胃组织和385例胃癌的临床病理特征进行了分析。进行统计分析以确定预后和诊断相关性。胃癌组织中GOLPH 2 mRNA和蛋白表达均显著高于癌旁组织。卡方检验和斯皮尔曼分析显示GOLPH 2的表达与临床分期、T分期、淋巴结转移、转移灶和静脉浸润密切相关。与GOLPH2表达较低的患者相比，GOLPH2表达较高的患者的总生存期（OS）较短。值得注意的是，我们的结果表明GOLPH2与GC的发展和进展相关。因此，需要进一步研究GOLPH 2作为GC新治疗靶点的潜力。
Golgi phosphoprotein 2 (GOLPH2) has been associated with the development and progression of various human cancers. The aims of this study were to investigate the relationship between GOLPH2 and gastric cancer (GC) progression and explore the clinical significance of GOLPH2 in GC. GOLPH2 expression was examined in four pairs of primary GC tissues and the adjacent non-cancerous tissues from the same patients, using immunohistochemistry (IHC), quantitative PCR and western blotting. Furthermore, GOLPH2 protein expression was analyzed in 10 normal gastric tissues and 385 clinicopathologically characterized cases of GC by IHC. Statistical analyses were performed to determine the prognostic and diagnostic associations. GOLPH2 mRNA and protein expression were both markedly upregulated in GC tissues, compared with the paired adjacent non-cancerous tissues. The Chi-square test and Spearman analysis revealed a significant correlation between GOLPH2 expression and clinical stage, T classification, lymph node metastasis, metastasis and venous invasion. Patients with a higher GOLPH2 expression had a shorter overall survival (OS), compared to patients with lower GOLPH2 expression. Notably, our results suggested that GOLPH2 is associated with the development and progression of GC. Therefore, additional studies focusing on the potential of GOLPH2 as a novel therapeutic target in GC are required.