Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging
Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging
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DOI：
10.1016/s0169-328x(97)00278-7
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发表时间：
1997-12-15
期刊：
影响因子：
--
通讯作者：
Nunes, V
中科院分区：
文献类型：
--
作者：
Barrientos, A;Casademont, J;Nunes, V
线粒体遗传系统在衰老退化过程中的作用尚不清楚。这项研究涉及人类大脑mtDNA表达的年龄相关变化。额叶皮层的脑组织来自13名年龄在21岁至84岁之间的人的尸检。线粒体DNA结构无明显变化，但随着年龄的增长，线粒体DNA含量增加，稳定水平的转录本和转录比（mtDNA/mtDNA）降低。这些结果表明，线粒体DNA水平的增加可以被认为是一种无效的补偿机制，以维持正常水平的mtDNA转录本。这种不平衡的线粒体状态可能在人脑衰老过程中发挥作用。(C)1997年Elsevier Science B.V.
The contribution of the mitochondrial genetic system in the degenerative processes of senescence remains unclear. This study deals with age-related changes in brain mtDNA expression in humans. Brain tissue from the frontal lobe cortex was obtained from autopsy of 13 humans aged between 21 and 84 years. No structural changes were detected in mtDNA, increased mtDNA content and reduced steady-slate level of mitochondrial transcripts and transcription ratio (mtRNA/mtDNA) were associated with aging. These findings suggest that the increase of the mtDNA levels could be considered as an inefficient compensatory mechanism to maintain the normal levels of mtRNA transcripts. This unbalanced mitochondrial condition could play a role in the process of senescence in human brain. (C) 1997 Elsevier Science B.V.