Synthesis of Oligodeoxyribonucleotides containing dimers with carbamate moieties as replacement of the natural phosphodiester linkage
Synthesis of Oligodeoxyribonucleotides containing dimers with carbamate moieties as replacement of the natural phosphodiester linkage
复制标题
含有氨基甲酸酯部分二聚体的寡脱氧核糖核苷酸的合成，作为天然磷酸二酯键的替代
DOI：
10.1016/0960-894x(94)80005-7
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发表时间：
1994
影响因子：
2.7
通讯作者：
J. Lebreton
中科院分区：
文献类型：
--
作者：
A. Waldner*;A. Mesmaeker;J. Lebreton
胸苷二聚体的合成含有两个可能的区域异构氨基甲酸酯部分的地方，天然磷酸二酯骨架描述。这些二聚体被纳入寡脱氧核糖核苷酸和DNA/RNA和DNA/DNA双链体的熔解温度（Tm）的报告。此外，测定了这些单链的核酸酶抗性。
The synthesis of thymidine dimers containing both possible regioisomeric carbamate moieties in place of the natural phosphodiester backbone is described. These dimers were incorporated in oligodeoxyribonucleotides and melting temperatures (Tm) of the DNA/RNA and DNA/DNA duplexes are reported. In addition the nuclease resistance of these single strands were determined.