Modeling Translation in Protein Synthesis with TASEP: A Tutorial and Recent Developments
Modeling Translation in Protein Synthesis with TASEP: A Tutorial and Recent Developments
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DOI：
10.1007/s10955-011-0183-1
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发表时间：
2011-04
影响因子：
1.6
通讯作者：
R. K. Zia;JiaJia Dong;JiaJia Dong;B. Schmittmann
中科院分区：
文献类型：
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作者：
R. K. Zia;JiaJia Dong;JiaJia Dong;B. Schmittmann
自 1968 年以来，蛋白质合成现象一直根据完全不对称简单排除过程 (TASEP) 进行建模。在本文中，我们提供了该方法的生物学和数学方面的教程。我们还总结了一些新结果，涉及细胞中的有限资源以及对具有不均匀跳跃率的 TASEP 当前（蛋白质生产率）的简单估计，反映了真实基因的特征。
The phenomenon of protein synthesis has been modeled in terms of totally asymmetric simple exclusion processes (TASEP) since 1968. In this article, we provide a tutorial of the biological and mathematical aspects of this approach. We also summarize several new results, concerned with limited resources in the cell and simple estimates for the current (protein production rate) of a TASEP with inhomogeneous hopping rates, reflecting the characteristics of real genes.