Development of heart inter-beat interval variability in preweanling rats: effects of exposure to alcohol and hypoxia.
Development of heart inter-beat interval variability in preweanling rats: effects of exposure to alcohol and hypoxia.
复制标题
断奶前大鼠心脏心跳间隔变异性的发展：暴露于酒精和缺氧的影响。
DOI：
10.1016/s0031-9384(96)00365-4
复制
发表时间：
1997
影响因子：
2.9
通讯作者：
Richards,JE
中科院分区：
文献类型：
--
作者：
Kelly,SJ;Richards,JE
凯利，S。J.和J. E.理查兹。断奶前大鼠心搏间期变异性的发展：暴露于酒精和缺氧的影响。Physiol Behav 61（2）231-241，1997年。本文研究了酒精暴露和低氧对断奶前大鼠心率和心搏间期变异性的影响。大鼠出生后第4天（PD）至12日人工饲养，从PD 4至10日暴露于酒精（5克/公斤/天）或缺氧（2 - 15分钟发作/天）。对照组包括人工饲养和正常饲养的大鼠，不暴露于酒精或缺氧。从PD 5至21，每隔一天记录20分钟的心率和呼吸。由呼吸性窦性心律失常（RSA）引起的心跳间间期和变异性的测量值从记录中计算出来。在这个年龄范围内，平均IBI稳步下降。从PD 5至15，RSA几乎没有变化，随后从PD 15至21，RSA水平大幅增加。酒精和缺氧暴露的大鼠在PD 19和21时RSA水平的增加显著较少。在PD 5、9和17时，所有组均发生大的心动过缓，并且在暴露于酒精或缺氧的大鼠中更普遍。这些数据表明，心脏变时功能的神经控制经历了重大的变化，在后期preweanling阶段，和神经控制的变化减缓缺氧或酒精暴露在出生后早期。
Kelly, S. J. and J. E. Richards. Development of heart inter-beat interval variability in preweanling rats: Effects of exposure to alcohol and hypoxia. Physiol Behav 61(2) 231–241, 1997.—The effect of alcohol exposure and hypoxia on the development of heart rate and heart inter-beat interval (IBI) variability was studied in preweanling rats. Rats were artificially reared from postnatal day (PD) 4 through 12 and either exposed to alcohol (5 g/kg/day) or hypoxia (2 15-min episodes/day) from PD 4 to 10. Control groups consisted of artificially reared and normally reared rats not exposed to alcohol or hypoxia. The heart rate and respiration was recorded for 20-min sessions every other day from PD 5 through 21. Inter-beat intervals and measures of their variability caused by respiratory sinus arrhythmia (RSA) were computed from the recordings. There was a steady decline in average IBI across this age range. There was little change in RSA from PD 5 to 15, followed by a large increase in RSA level from PD 15 to 21. The alcohol- and hypoxia-exposed rats showed significantly less increase in RSA level on PD 19 and 21. Large bradycardias occurred in all groups on PD 5, 9, and 17, and were more prevalent in rats exposed to alcohol or hypoxia. These data suggest that neural control of the chronotropic functions of the heart undergoes major changes in the late preweanling stage, and the changes in neural control are slowed by hypoxia or alcohol exposure during the early postnatal period.