Carcinogenic effect of carbazole in the liver of (C57BL/6N x C3H/HeN)F1 mice.
Carcinogenic effect of carbazole in the liver of (C57BL/6N x C3H/HeN)F1 mice.
复制标题
咔唑对 (C57BL/6N x C3H/HeN)F1 小鼠肝脏的致癌作用。
DOI：
10.1093/jnci/69.6.1383
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
N. Ito
中科院分区：
文献类型：
--
作者：
H. Tsuda;A. Hagiwara;M. Shibata;M. Ohshima;N. Ito
研究了咔唑(9H-咔唑)对(C57BL/6N X C3H/HEN)F1(B6C3F1)小鼠的致癌作用。每组50只小鼠，雌雄各半，给予含有0.6%、0.3%或0.15%咔唑的基础饲料96周，然后给予不添加任何添加剂的基础饲料，直到104周处死。存活超过52周的小鼠被包括在有效数量中。与对照组相比，给予咔唑的小鼠肝脏和前胃的肿瘤病变诱发率显著增加。肝脏病变分为肿瘤性结节和肝细胞癌两种类型。在服用咔唑的小鼠中，这两种类型病变的发生率几乎为100%，除雄性小鼠在饮食中添加0.6%咔唑外，其他所有小鼠的这两种类型病变的发生率都显著增加。肝细胞癌的发病率普遍高于肿瘤性结节。尽管没有统计学意义，但在服用咔唑组中发现肺转移发生率增加。在喂食0.6%咔唑的小鼠中，所有雌性和雄性小鼠的前胃肿瘤和乳头状瘤的发生率都显著增加。与对照组相比，给予0.6%咔唑的雄性小鼠的鳞状细胞癌诱发率显著不同。这些结果表明，咔唑对B6C3F1小鼠的肝脏和前胃具有致癌作用，并提示咔唑可能是一种与人类癌症风险相关的环境致癌物质。
The carcinogenic effect of carbazole (9H-carbazole) in (C57BL/6N X C3H/HeN)F1 (B6C3F1) mice was examined. Groups of 50 mice of both sexes were given a basal diet containing 0.6, 0.3, or 0.15% carbazole for 96 weeks and were then placed on an unsupplemented basal diet until they were killed at week 104. Mice surviving longer than 52 weeks were included in effective numbers. Significant increases in the induction of neoplastic lesions were found in the livers and forestomachs of mice given carbazole as compared to the control groups. The lesions in the livers were classified into two types, neoplastic nodules or hepatocellular carcinomas. The incidences of both types of lesions were almost 100% in mice treated with carbazole, and both types of lesions were significantly increased in all mice except the males given 0.6% carbazole in their diet. The incidences of hepatocellular carcinomas were in general higher than those of neoplastic nodules. Though not statistically significant, increased incidences of pulmonary metastases were found in the groups given carbazole. Significantly increased incidences of neoplastic lesions and papillomas in the forestomach in all groups of female and male mice were also noted in the mice fed 0.6% carbazole. Squamous cell carcinoma induction was significantly different in male mice given 0.6% carbazole as compared to controls. These results indicate that carbazole is carcinogenic to the liver and forestomach in B6C3F1 mice and suggest that carbazole may be an environmental carcinogen relevant to cancer risk in humans.