Isolation and structure determination of TMC-151s:: Novel polyketide antibiotics from Gliocladium catenulatum Gilman & Abbott TC 1280
Isolation and structure determination of TMC-151s:: Novel polyketide antibiotics from Gliocladium catenulatum Gilman & Abbott TC 1280
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DOI：
10.1016/s0040-4020(99)00408-1
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发表时间：
1999-06-18
期刊：
影响因子：
2.1
通讯作者：
Komatsubara, S
中科院分区：
文献类型：
--
作者：
Kohno, J;Nishio, M;Komatsubara, S
从土样中分离到6种新的抗生素TMC-151A-F(2-7)。它们的结构，包括绝对的立体化学，通过广泛的核磁共振和X射线结晶学分析以及降解研究确定。TMC-151是一种含有D-甘露糖苷和D-甘露醇或D-阿拉伯醇的新型聚酮化合物。这些抗生素对几种肿瘤细胞株表现出中等的细胞毒性。(C)1999爱思唯尔科学有限公司。保留所有权利。
Six new antibiotics, TMC-151 A-F (2-7) have been isolated from organic extracts of the fermentation broth of Gliocladium catenulatum Gilman & Abbott TC 1280, isolated from a soil sample. Their structures including the absolute stereochemistries, were determined by extensive analyses of NMR and X-ray crystallography, and degradation studies. TMC-151s are novel polyketides containing D-mannopyranoside and D-mannitol or D-arabitol. These antibiotics showed moderate cytotoxicity to several tumor cell lines. (C) 1999 Elsevier Science Ltd. All rights reserved.