Fully functional bioengineered tooth replacement as an organ replacement therapy
Fully functional bioengineered tooth replacement as an organ replacement therapy
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DOI：
10.1073/pnas.0902944106
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发表时间：
2009-08-11
影响因子：
11.1
通讯作者：
Tsuji, Takashi
中科院分区：
文献类型：
--
作者：
Ikeda, Etsuko;Morita, Ritsuko;Tsuji, Takashi
目前再生疗法的发展受到我们对胚胎发育，干细胞生物学和组织工程技术的理解的影响。再生治疗的最终目标是开发功能齐全的生物工程器官，与周围组织合作，以取代因疾病，损伤或衰老而丢失或损坏的器官。在这里，我们报告了一个成功的完全功能的牙齿替代成年小鼠通过生物工程牙胚移植到牙槽骨在失去的牙齿区域实现。我们提出这项技术作为未来器官替代疗法的模型。生物工程牙，这是萌出和封闭，具有正确的牙齿结构，矿化组织的咀嚼硬度，并响应有害刺激，如机械应力和疼痛与其他口腔颌面部组织的合作。这项研究代表了一个实质性的进步，并强调了生物工程器官替代在未来再生治疗中的潜力。
Current approaches to the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs which work in cooperation with surrounding tissues to replace organs that were lost or damaged as a result of disease, injury, or aging. Here, we report a successful fully functioning tooth replacement in an adult mouse achieved through the transplantation of bioengineered tooth germ into the alveolar bone in the lost tooth region. We propose this technology as a model for future organ replacement therapies. The bioengineered tooth, which was erupted and occluded, had the correct tooth structure, hardness of mineralized tissues for mastication, and response to noxious stimulations such as mechanical stress and pain in cooperation with other oral and maxillofacial tissues. This study represents a substantial advance and emphasizes the potential for bioengineered organ replacement in future regenerative therapies.