Taste loss with obesity in mice and men
Taste loss with obesity in mice and men
复制标题
DOI：
10.1038/s41366-019-0429-6
复制
发表时间：
2020-03-01
影响因子：
4.9
通讯作者：
Dando, Robin
中科院分区：
文献类型：
--
作者：
Kaufman, Andrew;Kim, Jennie;Dando, Robin
背景我们的味觉在定义我们的食物选择和习惯方面至关重要。味蕾主要位于我们的舌头上，是不断更新的感觉细胞的小集合体，其任务是在我们吃下的食物被消耗之前评估口腔刺激。方法使用小鼠和自由生活的人类群体，我们跟踪味觉乳头脱落与体重增加，以测试肥胖小鼠和肥胖增加的人类味觉系统的缺陷。结果喂食高脂饮食8周的小鼠表达的所有味觉细胞亚型的标记物水平低于喂食普通食物的小鼠。这伴随着味觉细胞增殖（Ki-67）和发育（β-连环蛋白）的标志物的丢失，以及较低的菌状乳头密度，与早期的结果一致，显示肥胖小鼠的轮廓味蕾丰度较低。同样，在一个追踪了4年大学入学的大学生群体中，菌状乳头密度的变化与颈围的变化呈负相关，颈围是肥胖的标志。菌状乳头位于舌头前部，是味蕾的所在。结论：这些结果强调了体重增加过程中味觉的变化，这是肥胖研究中一个潜在的重要考虑因素。
Background Our sense of taste is critical in defining our food choices and habits. Located primarily in our tongue, taste buds are small assemblies of constantly renewing sensory cells, tasked with evaluating oral stimuli before the food we eat is consumed. Methods Using both mice and a free-living human population, we tracked taste papilla abundancy with weight gain, to test for deficiencies in the taste system of obese mice and humans with increased adiposity. Results Mice fed a high-fat diet for 8 weeks expressed markers for all subtypes of taste cells at a lower level than chow-fed counterparts. This came alongside the loss of markers for taste cell proliferation (Ki-67) and development (beta-catenin), as well as lower fungiform papillae density, consistent with earlier results showing lower circumvallate taste bud abundance in obese mice. Likewise, in a population of college students tracked through 4 years of college attendance, the change in density of fungiform papillae, which house taste buds in the anterior tongue, was negatively correlated with change in neck circumference, a marker of adiposity. Conclusions These results highlight changes in taste during weight gain as a potentially important consideration in the study of obesity.