Blood Lymphocyte Surface Markers and Clinical Findings in Chronic Lymphoproliferative Disorders
Blood Lymphocyte Surface Markers and Clinical Findings in Chronic Lymphoproliferative Disorders
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慢性淋巴细胞增殖性疾病的血液淋巴细胞表面标志物和临床发现
DOI：
10.1111/j.1365-2141.1977.tb06836.x
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发表时间：
1977
影响因子：
6.5
通讯作者：
John L. Smith
中科院分区：
文献类型：
--
作者：
U. Jayaswal;S. Roath;R. D. Hyde;D. M. Chisholm;John L. Smith
本文对43例慢性淋巴细胞白血病（CLL）和5例淋巴瘤及外溢性白血病患者外周血淋巴细胞表面受体进行了研究。四分之一的CLL病例的淋巴细胞通过直接荧光抗体染色检测不到表面免疫球蛋白（SIG）。其余患者患有SIgM，其中三分之一的病例与SIgA相关。在临床表现上，70%的SIG阴性组有广泛的髓外受累（EMI），而35%的SIG阳性组有广泛的髓外受累（EMI），相应地，更多的SIG阴性组接受治疗。46%的SIg阴性组是超过3年的CLL患者，而SIgM + D组为9%，SIgM组为32%。这种模式的一些解释进行了讨论。
Surface receptors on peripheral blood lymphocytes have been studied in 43 cases with chronic lymphocytic leukaemia (CLL), and five cases with lymphoma and overspill. One quarter of the cases with CLL had lymphocytes with no detectable surface immunoglobulin (SIg) by direct fluorescent antibody staining. The remainder had SIgM, which was associated with SIgD in one third of the cases. 70% of the SIg negative group had extensive extramedullary involvement (EMI) compared with 3 5 % of the SIg positive group at presentation; correspondingly more of the SIg negative group were treated. 46% of the SIg negative group were CLL patients of more than 3 years standing compared with 9% of the SlgM + D group and 32% of the SIgM group. Some explanations for this pattern are discussed.