Altered brain activation by a false recognition task in young abstinent patients with alcohol dependence
Altered brain activation by a false recognition task in young abstinent patients with alcohol dependence
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DOI：
10.1111/j.1530-0277.2007.00453.x
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发表时间：
2007-09-01
影响因子：
3.2
通讯作者：
Suhara, Tetsuya
中科院分区：
文献类型：
--
作者：
Akine, Yoshihide;Kato, Motoichiro;Suhara, Tetsuya
背景：大量饮酒可引起中枢神经系统的结构和功能改变。最近的研究进展集中在这样一种观点上，即即使在没有明显大脑结构变化的酒精依赖患者中，也存在一些认知障碍，并且相关的功能变化可以通过神经成像技术可视化。然而，这些数据来自使用工作记忆和反应抑制任务的老年（50岁以上）患者。年轻的戒断患者是否表现出异常的大脑激活迹象是一个有趣的问题，特别是通过长期记忆检索任务。方法：研究对象为9例长期戒酒的年轻酒精依赖患者（男8例，女1例）和9例年龄和学历匹配的健康对照（男7例，女2例）。我们在功能性MRI研究中使用了一个改进的错误识别任务。结果：年轻酒精依赖患者的右背外侧前额叶皮层、前扣带皮层（ACC）、丘脑左侧枕状核和右腹侧纹状体的激活减少，尽管行为表现和脑激活的区域模式在患者和对照组之间相似。结论：长期记忆检索诱导年轻酒精依赖患者前额叶、ACC、丘脑和腹侧纹状体激活改变。这些发现与目标导向行为、监测错误反应、记忆功能和药物寻求行为的缺陷相对应。此外，这些减少的激活可以被认为是潜在的“病变”，表明酒精脑的亚临床病理。
Background: Heavy alcohol intake induces both structural and functional changes in the central nervous system. Recent research developments converged on the idea that even in patients with alcohol dependence without apparent structural brain changes, some cognitive impairment exists, and associated functional change could be visualized by neuroimaging techniques. However, these data were from old (more than 50 years) patients using working memory and response inhibition tasks. Whether young abstinent patients show aberrant signs of brain activation is a matter of interest, specifically by the long-term memory retrieval task. Methods: Subjects were 9 young patients with alcohol dependence with long-term abstinent (8 males and 1 female) and age- and education-matched 9 healthy controls (7 males and 2 females). We used a modified false recognition task in a functional MRI study. Results: The young patients with alcohol dependence showed reduced activation in the right dorsolateral prefrontal cortex, anterior cingulate cortex (ACC), left pulvinar in the thalamus, and in the right ventral striatum, although behavioral performances and regional patterns of brain activation were similar between patients and controls. Conclusions: Long-term memory retrieval induced altered activations in prefrontal lobes, ACC, thalamus, and ventral striatum in young patients with alcohol dependence. These findings were correspondent to deficits of goal directed behavior, monitoring the erroneous responses, memory function, and drug-seeking behavior. Furthermore, these reduced activations can be considered as latent "lesions," suggesting subclinical pathology in alcoholic brains.