Exercise for methamphetamine dependence: rationale, design, and methodology.
Exercise for methamphetamine dependence: rationale, design, and methodology.
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甲基苯丙胺依赖练习：基本原理、设计和方法。
DOI：
10.1016/j.cct.2013.11.010
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发表时间：
2014
影响因子：
2.2
通讯作者：
Rawson,RichardA
中科院分区：
文献类型：
--
作者：
Mooney,LarissaJ;Cooper,Christopher;London,EdytheD;Chudzynski,Joy;Dolezal,Brett;Dickerson,Daniel;Brecht,Mary-Lynn;Peñate,Jose;Rawson,RichardA
背景：治疗甲基苯丙胺（MA）依赖的有效药物疗法尚未确定，行为疗法效果甚微。基于行为研究证明有氧运动在改善抑郁症状、焦虑、认知缺陷和物质使用结果方面的潜在功效，本文描述的研究正在检验运动作为ma依赖个体的潜在治疗方法。方法：本研究随机抽取150名成瘾障碍住院治疗机构的MA依赖患者，接受每周三次有组织的有氧和阻力运动干预或健康教育条件。招聘工作于2010年3月开始。招生和后续阶段正在进行中，招生超过了目标入学率。结论：为了寻找治疗MA依赖的传统行为方法的可能有效辅助证据，本研究评估了8周有氧和阻力运动方案在出院后12周随访期间减少MA使用复发的能力。该研究还评估了方案实施期间和之后健康和功能结果的改善情况。本文介绍了本研究的设计和方法。
BackgroundEffective pharmacotherapies to treat methamphetamine (MA) dependence have not been identified, and behavioral therapies are marginally effective. Based on behavioral studies demonstrating the potential efficacy of aerobic exercise for improving depressive symptoms, anxiety, cognitive deficits, and substance use outcomes, the study described here is examining exercise as a potential treatment for MA-dependent individuals.MethodsThis study is randomizing 150 participants with MA dependence at a residential treatment facility for addictive disorders to receive either a thrice-weekly structured aerobic and resistance exercise intervention or a health education condition. Recruitment commenced in March, 2010. Enrollment and follow-up phases are ongoing, and recruitment is exceeding targeted enrollment rates.ConclusionsSeeking evidence for a possibly effective adjunct to traditional behavioral approaches for treatment of MA dependence, this study is assessing the ability of an 8-week aerobic and resistance exercise protocol to reduce relapse to MA use during a 12-week follow-up period after discharge from residential-based treatment. The study also is evaluating improvements in health and functional outcomes during and after the protocol. This paper describes the design and methods of the study.