Respiratory failure associated with human metapneumovirus infection in an infant posthepatic transplant
Respiratory failure associated with human metapneumovirus infection in an infant posthepatic transplant
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DOI：
10.1111/j.1600-6143.2008.02278.x
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发表时间：
2008-07-01
影响因子：
8.8
通讯作者：
Robinson, J. L.
中科院分区：
文献类型：
--
作者：
Evashuk, K. M. A.;Forgie, S. E.;Robinson, J. L.
这是第一例报告的呼吸衰竭与人类偏肺病毒（hMPV）感染的肝移植受者或儿科实体移植受者。一名9个月大的女性在肝移植后8天出现呼吸窘迫。检测到hMPV，她需要插管，然后进行体外膜肺氧合26天。除了甲基强的松龙作为急性呼吸窘迫的治疗外，在急性感染期间停用免疫抑制药物。连续多普勒超声用于监测肝血管血栓形成和血清肝功能检查，以评估肝功能障碍，没有移植物排斥反应的证据。患者从院内hMPV感染中恢复，肺功能满意，可能轻度发育迟缓。
This is the first reported case of respiratory failure associated with human metapneumovirus (hMPV) infection in a liver transplant recipient or in a pediatric solid transplant recipient. A 9-month-old female developed respiratory distress 8 days following a liver transplant. hMPV was detected and she required intubation followed by extracorporeal membrane oxygenation for 26 days. Immunosuppressive medications were stopped during the acute infection except for methylprednisolone as treatment for acute respiratory distress. Serial Doppler ultrasounds were used to monitor for hepatic vessel thromboses and serum liver function tests to assess for hepatic dysfunction and there was no evidence of allograft rejection. The patient recovered from the nosocomial hMPV infection with satisfactory pulmonary function and possible mild developmental delay.